Results 161 to 170 of about 21,308,721 (308)
Topological M-theory as unification of form theories of gravity [PDF]
, 2005 : We introduce a notion of topological M-theory and argue that it provides a unification of form theories of gravity in various dimensions. Its classical solutions involve $G_2$ holonomy metrics on 7-manifolds, obtained from a topological action for a 3 ...
Gukov, Sergei +7 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
L-InfinityAlgebras, Cohomology and M-Theory
, 2017 ConferenciaIn this introduction for topologists, we explain the role that extensions of L-infinity algebras by taking homotopy fibers plays in physics.
Huerta, John
core
Introduction : bringing back theory
, 2011 In a report in the New York Times about a public symposium on the future of theory held at University\ud of Chicago in 2002, staff writer Emily Eakin suggests that theory appears to have taken a back seat to\ud more pressing current affairs – the Bush ...
Mallan, Kerry M. +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Twisted Fibrations in M/F-theory
Journal of High Energy PhysicsIn this work we investigate 5-dimensional theories obtained from M-theory on genus one fibered threefolds which exhibit twisted algebras in their fibers.
Lara B. Anderson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Three-form periods on Calabi-Yau fourfolds: Toric hypersurfaces and F-theory applications
, 2017 The study of the geometry of Calabi-Yau fourfolds is relevant for compactifications of string theory, M-theory, and F-theory to various dimensions. This work introduces the mathematical machinery to derive the complete moduli dependence of the periods of
Sub String Theory Cosmology and ElemPart +5 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source