Results 141 to 150 of about 964,507 (280)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
M-Theory from Its Superalgebra [PDF]
, 1999 These lectures explore what can be learnt about M-theory from its superalgebra. The first three lectures introduce the 'basic' branes of M-theory, and type II superstring theories, and show how the duality relations between them are encoded in the respective spacetime superalgebras.
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ensembles in M-theory and holography
Journal of High Energy PhysicsWe discuss that the string/M-theory partition function requires a choice of ensembles, depending on which background fields are held fixed. The background fields correspond to worldvolume couplings in the effective action approach to the superstring ...
Friðrik Freyr Gautason +1 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Near-extremal membranes in M-theory
Journal of High Energy PhysicsWe consider near-extremal membranes embedded in M-theory, consistently truncated to gauged N $$ \mathcal{N} $$ = 2 supergravity in four dimensions on the coset space M 1,1,0.
Alex Buchel, Ruben Monten
doaj +1 more source
Axions, three-forms, and M-theory
Journal of High Energy PhysicsScalar fields with masses protected by global shift symmetries, commonly referred to as axions, are abundantly used in effective field theories in cosmology and particle physics.
Florian Niedermann, Ziqi Yan
doaj +1 more source