Results 161 to 170 of about 709,638 (304)

Optimized Mass Spectrometry to Uncover M. tuberculosis Biomarkers in Extracellular Vesicles from Asymptomatic Tuberculosis Patients. [PDF]

J Infect Dis
Nieto Ramirez LM, Shelton K, Belisle JT, Diaz G, Tameris M, Naidoo K, Churchyard G, Scriba T, Walzl G, Sterling TR, Hadley K, Mulenga H, Hatherill M, Dobos KM.   +13 more
europepmc   +1 more source

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

DNA Fingerprinting and Phenotyping of Mycobacterium Tuberculosis Isolates from Human Immunodeficiency Virus (HIV)-Seropositive and HIV-seronegative Patients in Tanzania. [PDF]

With the purpose of determining whether the risk of infection with a particular clone of Mycobacterium tuberculosis is influenced by the human immunodeficiency virus (HIV) status of the host, we analyzed and compared 68 mycobacterial isolates obtained ...
Yang, Z H, Mtoni, I, Chonde, M, Mwasekaga, M, Fuursted, K, Askgård, D S, Bennedsen, J, de Haas, P E, van Soolingen, D, van Embden, J D   +9 more
core  

Tamoxifen inhibits histidine kinases of <i>M. tuberculosis</i> two-component signaling systems. [PDF]

Microbiol Spectr
Garg A, Singh DP, Pandit M, Malhotra V, Saini DK.   +4 more
europepmc   +1 more source

Measurement of Active Thrombin Bound to Circulating D‐Dimers as a Sensitive Biomarker for Prothrombotic Conditions

Journal of Clinical Laboratory Analysis, EarlyView.
Scheme of preparation of D‐dimers and evaluation of D‐dimer‐bound thrombin activity. Thrombin bound to fibrin participates in ongoing fibrinogen transformation and its inhibition is impeded. Our detection system may aid in identifying patients at risk of recurrent thrombotic events or complications, regardless of the origin of the acute health problem.
Jana Stikarova, Leona Chrastinova, Kristyna Svobodova, Marek Havlicek, Jan Louzil, Eliska Ceznerova, Alzbeta Hlavackova, Ondrej Pastva, Pavla Pecherkova, Ingrid Hrachovinova, Ondrej Kucerka, Roman Kotlin, Petr Soukup, Peter Salaj, Martin Maly, Jiri Suttnar   +15 more
wiley   +1 more source

The ubiquitin ligase CBL and Fas-associated factor 2 cooperate to regulate the innate immune response to M. tuberculosis. [PDF]

PLoS Pathog
Truong T, Ray A, Martin K, Bates NA, Salemi M, Phinney BS, Penn BH.   +6 more
europepmc   +1 more source

Diagnostic Performance of Comprehensive Point‐of‐Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study

Journal of Clinical Ultrasound, EarlyView.
In children with presumptive tuberculosis, comprehensive point‐of‐care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter‐reader reliability. Although diagnostic sensitivity was modest and examinations often incomplete, cPOCUS shows promise as a complementary, radiation‐free imaging tool.
Isabelle Munyangaju, Antoni Noguera‐Julian, Aleix Soler‐Garcia, Antoni Soriano‐Arandes, José Miguel Escudero Fernández, Maria Espiau, Begoña Santiago Garcia, Alicia Hernanz‐Lobo, Ángel M. Lancharro Zapata, Enrique Ladera, Angela Manzanares, Daniel Blazquez, Elisa Aguirre Pascual, Isabelle Thierry‐Chef, Danilo Buonsenso, Xavier Serres‐Créixams, Quique Bassat, Elisa Lopez‐Varela   +17 more
wiley   +1 more source

A tiled amplicon protocol for culture-free whole-genome sequencing of <i>M. tuberculosis</i> from clinical specimens. [PDF]

J Clin Microbiol
Kalinich CC, Gonzalez FL, Osmaston A, Breban MI, Distefano I, Leon C, Coronel J, Tan G, Crudu V, Ciobanu N, Codreanu A, Solano W, Ráez J, Sheen P, Zimic M, Allicock OM, Chaguza C, Wyllie AL, Brandt M, Weinberger DM, Sobkowiak B, Cohen T, Grandjean L, Grubaugh ND, Redmond SN.   +24 more
europepmc   +1 more source

Sonographic Diagnosis of an Intercostal Artery Pseudoaneurysm: A Case Report and Literature Review

Journal of Clinical Ultrasound, EarlyView.
A 63‐year‐old male presented to the emergency department after being found unconscious during a welfare check. Following a prolonged three‐month hospital admission, the patient developed left flank pain. Spectral Doppler ultrasound revealed a large isoechoic lesion with layering echoes, and spectral Doppler demonstrated bidirectional flow.
Aaditya P. Singh, Peter R. Coombs
wiley   +1 more source

The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators

Journal of Hospital Medicine, EarlyView.
Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield, Amal Mohamed, Shuhan He, Cory Rohlfsen   +3 more
wiley   +1 more source