Results 221 to 230 of about 24,558,315 (312)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Recombinant BCGΔBCG1419c protects outbred mice against M. tuberculosis challenge. [PDF]

Vaccine
Kurtz SL, Gould V, Flores-Valdez MA, Elkins KL.   +3 more
europepmc   +1 more source

Diverse Uses of Lantibiotics: Exploring New Approaches to Combat Antibiotic Resistance

Medicine Advances, EarlyView.
This review illustrates lantibiotics as an alternative therapeutic approach to combat antibiotic resistance, highlighting their diverse sources, including plants, insects, animals, and microorganisms. It further emphasizes their broad therapeutic potential, including antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities (GA ...
Gopalarethinam Janani, Shangavy Pandiarajan, Kunal Biswas, Manickam Rajkumar, Agnishwar Girigoswami, Koyeli Girigoswami   +5 more
wiley   +1 more source

Stopping Tuberculosis at the Gate: The Role of <i>M. tuberculosis</i> Adhesins in Infection and Intervention. [PDF]

Vaccines (Basel)
Yang H, Ma Y, Lei X, Chai S, Zhang S, Su G, Li S, Du L.   +7 more
europepmc   +1 more source

On the analyzing of bifurcation properties of the one‐dimensional Mackey–Glass model by using a generalized approach

Mathematical Methods in the Applied Sciences, EarlyView.
The goal of this work is to look at how a nonlinear model describes hematopoiesis and its complexities utilizing commonly used techniques with historical and material links. Based on time delay, the Mackey–Glass model is explored in two instances. To offer a range, the relevance of the parameter impacting stability (bifurcation) is recorded.
Shuai Zhang, Yaya Wang, Hongyin Geng, Wei Gao, Esin Ilhan, Haci Mehmet Baskonus   +5 more
wiley   +1 more source

The Intricate Process of Calcification in Granuloma Formation and the Complications Following <i>M. tuberculosis</i> Infection. [PDF]

Biomolecules
Yedgarian N, Agopian J, Flaig B, Hajjar F, Karapetyan A, Murthy K, Patrikyan A, Tomas K, Tumanyan K, Nasiri MJ, Subbian S, Venketaraman V.   +11 more
europepmc   +1 more source

Investigating Tuberculosis Dynamics Under Various Control Strategies: A Comprehensive Analysis Using Real Statistical Data

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In the present investigation, a mathematical model with vaccination, treatment, and environmental impact under real data is presented. Initially, we present the model without any interventions, followed by an examination of its equilibrium points.
Bashir Al‐Hdaibat, Mahmoud H. DarAssi, Irfan Ahmad, Muhammad Altaf Khan, Reem Algethamie   +4 more
wiley   +1 more source

First insights into the genetic composition of <i>M. tuberculosis</i> population circulating in Kosovo. [PDF]

J Clin Tuberc Other Mycobact Dis
Minias A, Kuzioła M, Ahmeti F, Mehmeti N, Jerliu B, Lila G, Miftari A, Shkodra X, Jakupi X, Kacaniku Z, Kozińska M, Zabost A, Słomka M, Strapagiel D, Dziadek J, Augustynowicz-Kopeć E, Bajrami R.   +16 more
europepmc   +1 more source

Toxoplasma gondii Infection After Kidney Transplantation: A Case Report and Literature Review

Organ Medicine, EarlyView.
Toxoplasma gondii infection after kidney transplantation is rare and presents with nonspecific clinical manifestations; however, the associated mortality rate is high. We discuss the relevant literature, clinical manifestations, therapeutic regimens, and prognoses of post‐transplantation toxoplasmosis.
Peng Zhang, Xingqiang Lai, Rongxin Chen, Li Li, Jiali Fang, Guanghui Li, Junjie Ma, Luhao Liu, Zheng Chen   +8 more
wiley   +1 more source

Chalkophore-mediated respiratory oxidase flexibility controls <i>M. tuberculosis</i> virulence. [PDF]

Elife
Buglino JA, Ozakman Y, Hatch CE, Benjamin A, Tan DS, Glickman MS.   +5 more
europepmc   +1 more source