Results 221 to 230 of about 1,738,596 (334)

Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.

JAMA Netw Open
Martinelli E, Ke J, Khan A, Wongboonsin J, Vanderwall DR, Lim TY, Santoriello D, Gupta Y, McNulty MT, Koyama S, Puntambekar S, Bomback AS, Canetta P, Kretzler M, Montini G, Morello W, Maggiore U, Fiaccadori E, Gesualdo L, Ghiggeri GM, Oliveira EA, Simoes E Silva AC, Bendapudi PK, Motelow J, Garcia CK, Paul DS, Petrovski S, Goldstein DB, Friedman DJ, Radhakrishnan J, Lin F, Mohan S, Appel GB, Saleem MA, Natarajan P, Hildebrandt F, Westland R, D'Agati VD, Gbadegesin R, Gharavi AG, Pollak MR, Kiryluk K, Sampson MG, Sanna-Cherchi S, Columbia Genomics Consortium.   +44 more
europepmc   +1 more source

Oral Administration of Itraconazole Induces M1 Polarization of Tumor-associated Macrophages in Gynecological Cancer. [PDF]

In Vivo
Ueda T, Tsubamoto H, Taniguchi R, Takimoto Y, Sakata K, Narita S, Iwamoto M, Nakabayashi M, Wakimoto YU, Sasano T, Mibayashi S, Ohe C, Mabuchi S.   +12 more
europepmc   +1 more source

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, EarlyView.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Acute ischemic stroke in a twig-like middle cerebral artery: A case report and review of etiology and thrombectomy risks. [PDF]

Surg Neurol Int
Tsukagoshi E, Sato H, Ogura T, Ohmori S.
europepmc   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Inhibitory effects of spermidine on lipopolysaccharide-induced inflammation in RAW 264.7 cells. [PDF]

Exp Ther Med
Yuan H, Peng F, Zhou YF, Wu SX, Long ZY, Peng YM, Zhou YZ.   +6 more
europepmc   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

ω-3 PUFAs Attenuate Postoperative Ileus by Modulating Macrophage Polarization via the JAK2/STAT3 Signaling Pathway. [PDF]

J Inflamm Res
Zhao X, Yu J, Zhang T, Zhang Y, Zhang L, Wang Y, Yi C, Pan H, Wang H, Ge M, Jiang Z, Wang G.   +11 more
europepmc   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements. [PDF]

iScience
Gorkowska-Nosal M, Drwiega G, Szumiec L, Rodriguez Parkitna J, Cieslak PE.   +4 more
europepmc   +1 more source