Results 251 to 260 of about 1,738,596 (334)

Proline-Mediated Inhibition of ATPIF1-mTOR Signaling Alleviates Radiation-Induced Macrophage Polarization and Colon Inflammation. [PDF]

Inflammation
Chang L, Zhou L, Jiang S, Wei K, Li J, Zhao J, Shah K, Deng X, Sun R, Zuo X, Wang Z, Ding L, Luo Z, Duan L, Yan Y.   +14 more
europepmc   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration. [PDF]

Skelet Muscle
Liu J, Li N, Jing S, Wu F, An G, Wang L, Li J, Cao X, Sun J.   +8 more
europepmc   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Asbestos Disease Initiation. [PDF]

Bull Math Biol
DeStefano A, Martin C, Wallace D.
europepmc   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

Advanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler, Michael Halwes, David J. Collins   +2 more
wiley   +1 more source

NIR-II imaging-guided nanoplatform for synergistic mitochondria-targeted pyroptosis and macrophage reprogramming immunotherapy. [PDF]

Mater Today Bio
Zhang D, He X, Vinodh K, Yao Z, Wei W, Liang J, Li N, Wu Z, Li S.   +8 more
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Hybrid kernels integrating genomic and multispectral data improve wheat genomic prediction accuracy. [PDF]

Plant Genome
Montesinos-López OA, Martínez-Regalado JA, Murillo-Avalos CL, Herr AW, Montesinos-López A, Delgado-Enciso I, Cuevas J, Crossa J, Carter AH.   +8 more
europepmc   +1 more source