Results 291 to 300 of about 1,738,596 (334)

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages.

Biomaterials, 2021
M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized, anti-tumoral macrophages. In this study, we harnessed M1 macrophage-derived exosomes engineered to foster
Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, M. Baek, Byungheon Lee   +3 more
semanticscholar   +1 more source

OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy.

Journal of Controlled Release, 2023
With only limited clinical patient benefit, focusing on new immune checkpoint pathways could be an important complement to current immune checkpoint drugs.
Yongkang Yu, Tingxuan Li, Meitong Ou, Ran Luo, Hongzhong Chen, He Ren, Zimu Li, Jie Sun, Hanjie Zhang, Shaojun Peng, Yanli Zhao, Lin Mei   +11 more
semanticscholar   +1 more source

MiniMax-M1: Scaling Test-Time Compute Efficiently with Lightning Attention

arXiv.org
We introduce MiniMax-M1, the world's first open-weight, large-scale hybrid-attention reasoning model. MiniMax-M1 is powered by a hybrid Mixture-of-Experts (MoE) architecture combined with a lightning attention mechanism.
MiniMax Aili Chen, Aonian Li, Bangwei Gong, Binyan Jiang, Bo Fei, Bo Yang, Boji Shan, Changqing Yu, Chao Wang, Cheng Zhu, Chengjun Xiao, Chengyu Du, Chi Zhang, Chu Qiao, Chunhao Zhang, Chunhui Du, Congchao Guo, Da Chen, Deming Ding, Dianjun Sun, Dong Li, Enwei Jiao, Haigang Zhou, Haimo Zhang, Han Ding, Haohai Sun, Hao Feng, Huaiguang Cai, Haichao Zhu, Jian Sun, Jiaqi Zhuang, Jia-Yao Cai, Jiayuan Song, Jin Zhu, Jingyang Li, Jinhao Tian, Jinli Liu, Junhao Xu, Junjie Yan, Junteng Liu, Junxia He, Kaiyi Feng, Ke Yang, Ke Xiao, Le Han, Leyang Wang, Lian-Chun Yu, Li Feng, Lin Li, Lin Zheng, Linge Du, Li-na Yang, Lu Zeng, Ming-Yuan Yu, Mingliang Tao, Mingyuan Chi, Mozhi Zhang, Mujie Lin, Nan Hu, Nongyu Di, Peng Gao, Pengfei Li, Peng Zhao, Qibing Ren, Qidi Xu, Qile Li, Qin Wang, Rong Tian, Ruitao Leng, Shaoxiang Chen, Shaoyu Chen, Shengmin Shi, Shitong Weng, Shuchang Guan, Shu Yu, Si-Jie Li, S. Zhu, Tengfei Li, Tian-Yi Cai, Tianrun Liang, Weiyu Cheng, Weize Kong, Wenkai Li, X. Chen, Xiangjun Song, Xiao Luo, Xiaoyan Su, Xiaobo Li, Xiaodong Han, Xi-Yong Hou, Xuan-wen Lu, Xun Zou, Xuyang Shen, Yanting Gong, Yan Ma, Yang Wang, Yiqi Shi, Yi-Fan Zhong, Yonghong Duan, Yongxiang Fu, Yong Hu, Yu Gao, Yuanxiang Fan, Yufeng Yang, Yuhao Li, Yulin Hu, Yunan Huang, Yunji Li, Yun Xu, Yuxin Mao, Yu-Zhe Shi, Yuze Wenren, Zehan Li, Zelin Li, Z. Tian, Zhengmao Zhu, Zhe-Yu Fan, Zhenzhen Wu, Zhichao Xu, Zhihang Yu, Z. Lyu, Zhuo Jiang, Zibo Gao, Zijia Wu, Zijian Song, Zijun Sun   +125 more
semanticscholar   +1 more source

Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis.

Journal of Periodontal Research, 2021
BACKGROUND AND OBJECTIVE Periodontitis in diabetic patients is characterized by enhanced inflammation and aggravated tissue damage in comparison with that in non-diabetic counterparts. The progression of periodontal damage under diabetic condition can be
Bo Zhang, Yang Yang, Jianru Yi, Zhihe Zhao, Rui Ye   +4 more
semanticscholar   +1 more source

M1-D

2023
M1 ...
openaire   +2 more sources

NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption.

Journal of Clinical Periodontology, 2020
AIMS To explore the involvement of NOD-like receptor protein 3 (NLRP3) inflammasome and M1 macrophage in root resorption (RR). METHODS A rat RR model was established by excessive orthodontic force.
Jie Zhang, Xinqiang Liu, Chunyan Wan, Yang Liu, Yaqi Wang, Chenda Meng, Yipeng Zhang, Chunmiao Jiang   +7 more
semanticscholar   +1 more source

N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation.

Cellular Signalling, 2020
Macrophage polarization is the driving force of various inflammatory diseases, especially those involved in M1/M2 imbalance. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes that affects multiple biological ...
Xiaofei Gu, Yiwen Zhang, Di Li, H. Cai, Luhui Cai, Qiong Xu   +5 more
semanticscholar   +1 more source

Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review.

Autoimmunity Reviews, 2019
BACKGROUND AND AIM Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease; the clinical manifestations are correlated with continuum multiarticular synovitis, cartilage and bone damage, and defeat of joint function, that causes disability.
S. Tardito, G. Martinelli, S. Soldano, S. Paolino, G. Pacini, M. Patané, E. Alessandri, V. Smith, M. Cutolo   +8 more
semanticscholar   +1 more source

TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages.

Cancer Letters, 2020
Resistance to oxaliplatin is a major obstacle hindering the clinical treatment of colorectal cancer, but the underlying immunological mechanism has not yet been well illustrated. As a pivotal immunosuppressive component in tumor microenvironment, myeloid-
Zhipeng Liu, Yue Xie, Yao Xiong, Siliang Liu, C. Qiu, Zhenhao Zhu, Hua Mao, Meng Yu, Xinying Wang   +8 more
semanticscholar   +1 more source

Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease

Gynecological Endocrinology, 2020
Endometriosis is an estrogen-dependent disease defined by the presence and growth of functional endometrial-like tissue, glands and stroma, outside the uterine cavity.
A. Laganà, F. Salmeri, H. Ban Frangež, F. Ghezzi, E. Vrtačnik-Bokal, R. Granese   +5 more
semanticscholar   +1 more source