Results 1 to 10 of about 180,585 (312)

The muscarinic M1 receptor modulates associative learning and memory in psychotic disorders [PDF]

NeuroImage: Clinical, 2020
Background: Psychotic disorders are characterized by prominent deficits in associative learning and memory for which there are currently no effective treatments.
Geor Bakker, Claudia Vingerhoets, Oswald J.N. Bloemen, Barbara J. Sahakian, Jan Booij, Matthan W.A. Caan, Thérèse A.M.J. van Amelsvoort   +6 more
doaj   +2 more sources

M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. [PDF]

PLoS ONE, 2013
HEK293 cells have been used extensively to generate stable cell lines to study G protein-coupled receptors, such as muscarinic acetylcholine receptors (mAChRs).
E Scott Graham, Kerhan K Woo, Miranda Aalderink, Sandie Fry, Jeffrey M Greenwood, Michelle Glass, Mike Dragunow   +6 more
doaj   +4 more sources

Flavonoids with M1 Muscarinic Acetylcholine Receptor Binding Activity [PDF]

Molecules, 2014
Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer’s disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at ...
Meyyammai Swaminathan, Chin Fei Chee, Sek Peng Chin, Michael J. C. Buckle, Noorsaadah Abd. Rahman, Stephen W. Doughty, Lip Yong Chung   +6 more
doaj   +3 more sources

Electroacupuncture stimulation induced M1/M2 polarization in white adipose tissues by activating the Y1 receptor in obese mice to reduce chronic inflammation

Adipocyte
Chronic inflammation in obesity can induce complications such as diabetes and cardiovascular disease. Visceral adipose tissue is the main source of inflammation, but it is difficult to regulate effectively.
Mengjiang Lu, Ziwei Yu, Xingyu Yang, Ze Yang, Tiancheng Xu, Zhi Yu, Xinyue Jing, Li An, Jianbin Zhang, Bin Xu   +9 more
doaj   +2 more sources

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Journal of Pharmacological Sciences, 2008
The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious ...
Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano   +6 more
doaj   +3 more sources

M1 receptor positive allosteric modulators discovery approaches

Trends in Pharmacological Sciences
The development of M1 muscarinic acetylcholine-receptor-positive allosteric modulators has been hindered by their limited cognitive efficacy and cholinergic side effects. We discuss two unique approaches - low intrinsic agonism and low binding cooperativity - that were developed to address these issues and their therapeutic implications.
Takao Mandai, Arthur A. Simen, Antonio Laurenza, Haruhide Kimura   +3 more
openalex   +3 more sources

IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia

Pharmacological Research
Cobenfy, a co-formulation of xanomeline and trospium, is the first drug not acting on the dopaminergic system of the CNS approved for the treatment of schizophrenia by the FDA.
Brian Dean
doaj   +2 more sources

M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]

Neuroscience Bulletin, 2014
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified.
Jiang, Shangtong, Li, Yanfang, Zhang, Cuilin, Zhao, Yingjun, Bu, Guojun, Xu, Huaxi, Zhang, Yun-Wu   +6 more
openaire   +3 more sources

Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor (mAChR) M1 in the eyes of guinea pigs.
Yuan Tao, Xiao-Li Li, Li-Yuan Sun, Yu-Hua Wei, Xiao-Ting Yu, Hong Wang   +5 more
doaj   +1 more source

Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice

Journal of Pharmacological Sciences, 2020
Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the
Keisuke Migita, Akiko Nishimura, Fumihiro Eto, Kohei Koga, Taichi Matsumoto, Kazuki Terada, Shuji Hara, Kenji Honda   +7 more
doaj   +1 more source