Results 171 to 180 of about 180,585 (312)

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Diffusion and Oligomerization States of the Muscarinic M₁ Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. [PDF]

J Phys Chem B
Zhou X, Septien-Gonzalez H, Husaini S, Ward RJ, Milligan G, Gradinaru CC.   +5 more
europepmc   +1 more source

TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys. [PDF]

PLoS One, 2019
Kurimoto E, Nakashima M, Kimura H, Suzuki M.   +3 more
europepmc   +1 more source

Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors

, 2020
Marco Maspero, Daniela Volpato, Davide Cirillo, Natalia Yuan Chen, Regina Messerer, Christoph Sotriffer, Marco De Amici, Ulrike Holzgrabe, Clelia Dallanoce   +8 more
openalex   +2 more sources

Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB/BDNF expression and impeding TLR-4/NFκBp65/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats

, 2022
Sahar S. Abd El‐Rahman, Hany M. Fayed
openalex   +2 more sources

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation [PDF]

, 1995
Allan I. Levey, S.M. Edmunds, Vassilis E. Koliatsos, R.G. Wiley, CJ Heilman   +4 more
openalex   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Safety and Pharmacokinetics of HTL0018318, a Novel M₁ Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects. [PDF]

Drugs R D, 2021
Bakker C, van der Aart J, Labots G, Liptrot J, Cross DM, Klaassen ES, Dickinson S, Tasker T, Groeneveld GJ.   +8 more
europepmc   +1 more source

Pulmonary M1 muscarinic receptors in the rabbit

Pathophysiology, 1994
S. Matsumoto, T. Kanno, T. Nagayama, M. Yamasaki, S. Shimizu   +4 more
openaire   +1 more source