Results 261 to 270 of about 180,585 (312)

Two affinity states of M1 muscarine receptors

Cellular and Molecular Neurobiology, 1988
1. The binding of oxotremorine-M to M1 muscarine receptors was examined by measuring competition between the agonist and 3H-pirenzepine, using rabbit hippocampal membranes suspended in 20 mM Tris buffer containing 1 mM Mn2+. 2. Both ligands interacted with a single class of receptors.
L T, Potter, C A, Ferrendelli, H E, Hanchett   +2 more
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Stable allosteric binding of m1-toxin to m1 muscarinic receptors.

Molecular Pharmacology, 1993
m1-Toxin was found to slow the dissociation of [3H]N-methyl-scopolamine (NMS) and [3H]pirenzepine from m1 muscarinic receptors expressed in the membranes of Chinese hamster ovary cells. When toxin-NMS-receptor complexes were formed in membranes and then dissolved in digitonin, or when these complexes were formed in solution, the toxin completely ...
S I, Max, J S, Liang, L T, Potter
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M1 and M3 muscarinic receptors

NeuroReport, 1992
P-fluoro-hexahydro-sila-difenidol hydrochloride (p-F-HHSiD) (15, 30 micrograms) and pirenzepine (7.5, 15, 30 micrograms), which are highly selective M3 and M1 muscarinic antagonists, respectively, were injected intracerebroventricularly into freely moving rats.
L. IMERI, S. BIANCHI, P. ANGELI, M. MANCIA   +3 more
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Selectivity of oxomemazine for the M1 muscarinic receptors

Archives of Pharmacal Research, 1994
The binding characteristics of pirenzepine and oxomemazine to muscarinic receptor were studied to evaluate the selectivity of oxomemazine for the muscarinic receptor subtypes in rat cerebral microsomes. Equilibrium dissociation constant (KD) of (-)-[3H]quinuclidinyl benzilate([3H]QNB) determined from saturation isotherms was 64 pM.
S W, Lee, C W, Woo, J G, Kim
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Use of m1-toxin as a selective antagonist of m1 muscarinic receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1993
m1-Toxin is the only ligand which is known to bind specifically to the extracellular face of genetically defined m1 muscarinic receptors; it binds pseudoirreversibly. A variety of studies were performed to evaluate the usefulness of m1-toxin as a selective antagonist of m1 receptors.
S I, Max, J S, Liang, H H, Valentine, L T, Potter   +3 more
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Agonist induced phosphorylation of M1 muscarinic receptors

Life Sciences, 1995
73039
WAUGH, MG, NAHORSKI, S, TOBIN, AB
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Carbachol induces desensitization of cardiac β-adrenergic receptors through muscarinic M1 receptors

Biochemical and Biophysical Research Communications, 1985
Incubation of enzymatically dissociated cardiac myocytes with carbachol leads to a time- and concentration-dependent loss of beta-receptors assayable with [3H]CGP-12177. This loss is due to a redistribution of beta-receptors from the plasma membrane to a cytosol-derived vesicular fraction, consistent with an internalization process.
C J, Limas, C, Limas
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Muscarinic M1, M2 receptor binding. Relationship with functional efficacy

European Journal of Pharmacology, 1988
A comparison has been made between [3H]pirenzepine binding to the M1 receptor population of rat cerebral cortex and [3H]N-methylscopolamine binding to M2 receptors in rat cardiac membranes. Several standard muscarinic antagonists including trihexyphenidyl HCl, benztropine, biperidin and 4-DAMP (4-diphenylacetoxy-N-methyl piperidine methiodide) showed ...
S B, Freedman, M S, Beer, E A, Harley
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