Results 21 to 30 of about 180,585 (312)

Vitamin E can compensate the density of M1 receptors in the hippocampus of scopolamine-treated rats

Folia Neuropathologica, 2018
M1 muscarinic receptor plays a fundamental role in memory and is closely associated with Alzheimer’s disease (AD); it has long been assumed as a therapeutic goal. By activating of the cholinergic receptor vitamin E helps with memory retention.
Ali Sayyahi, Mehrdad Jahanshahi, Hossein Amini, Hamid Sepehri   +3 more
doaj   +1 more source

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways ...
Yong Shi, Yong Shi, Yong Shi, Yong Shi, Yong Shi, Wantong Su, Wantong Su, Wantong Su, Wantong Su, Wantong Su, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Peng Wang, Peng Wang, Peng Wang, Peng Wang, Peng Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Song Wei, Song Wei, Song Wei, Song Wei, Song Wei, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Johan Auwerx, Kristina Schoonjans, Yue Yu, Yue Yu, Yue Yu, Yue Yu, Yue Yu, Rui Pan, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +67 more
doaj   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +1 more source

Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats. [PDF]

PLoS ONE, 2013
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus ...
Chen Yang, Shun-Nan Ge, Jia-Rui Zhang, Lei Chen, Zhi-Qiang Yan, Li-Jun Heng, Tian-Zhi Zhao, Wei-Xin Li, Dong Jia, Jun-Ling Zhu, Guo-Dong Gao   +10 more
doaj   +1 more source

Coincidence Signaling of Dopamine D1-Like and M1 Muscarinic Receptors in the Regulation of Cyclic AMP Formation and CREB Phosphorylation in Mouse Prefrontal Cortex

Neurosignals, 2012
In the prefrontal cortex, dopamine D1-like and M1 muscarinic receptors are both involved in the regulation of attentional, cognitive and emotional processes but so far no information has been provided on their functional interaction. In the present study
Maria C. Olianas, Simona Dedoni, Pierluigi Onali   +2 more
doaj   +1 more source

Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors [PDF]

Biochemical Journal, 1999
Pre-stimulation of Chinese hamster ovary (CHO) cells expressing the human m1-muscarinic receptor (CHO-m1 cells) with a maximally effective concentration of the muscarinic agonist methacholine resulted in desensitization of Ins(1,4,5)P3 accumulation, apparent as a ∼ 4-fold shift in the agonist dose–response curve.
Waugh, MG, John Challiss RA, Berstein, G, Nahorski, SR, Tobin, AB   +4 more
openaire   +3 more sources

Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Journal of Pharmacological Sciences, 2018
The role of the GABAB receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABAB receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats.
Keisuke Migita, Yu Matsuzaki, Kohei Koga, Taichi Matsumoto, Kenichi Mishima, Shuji Hara, Kenji Honda   +6 more
doaj   +1 more source

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer

OncoImmunology, 2021
Irreversible electroporation (IRE) is an effective method for treating pancreatic ductal adenocarcinoma (PDAC). It remains unclear whether IRE can induce a specific immune response by stimulating macrophages.
Chaobin He, Shuxin Sun, Yu Zhang, Fengxiao Xie, Shengping Li   +4 more
doaj   +1 more source

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein

Toxins, 2011
Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja, Johnny Näsman, Sergio Rondinelli   +2 more
doaj   +1 more source

M1 and M4 Receptors Modulate Hippocampal Pyramidal Neurons

Journal of Neurophysiology, 2011
Acetylcholine (ACh), acting at muscarinic ACh receptors (mAChRs), modulates the excitability and synaptic connectivity of hippocampal pyramidal neurons. CA1 pyramidal neurons respond to transient (“phasic”) mAChR activation with biphasic responses in which inhibition is followed by excitation, whereas prolonged (“tonic”) mAChR activation increases CA1 ...
Sameera, Dasari, Allan T, Gulledge
openaire   +3 more sources