Results 61 to 70 of about 180,585 (312)

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

open access: yesAdvanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz   +7 more
wiley   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

open access: yesFrontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao   +4 more
doaj   +1 more source

Transcriptome profiling reveals new insights into the roles of neuronal nitric oxide synthase on macrophage polarization towards classically activated phenotype.

open access: yesPLoS ONE, 2021
In response to various stimuli, naïve macrophages usually polarize to M1 (classically activated) or M2 (alternatively activated) cells with distinct biological functions.
Pingan Chang   +4 more
doaj   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

open access: yesAdvanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li   +10 more
wiley   +1 more source

Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp.

open access: yesPLoS ONE, 2012
In order to kill competing strains of the same or closely related bacterial species, many bacteria produce potent narrow-spectrum protein antibiotics known as bacteriocins. Two sequenced strains of the phytopathogenic bacterium Pectobacterium carotovorum
Rhys Grinter, Joel Milner, Daniel Walker
doaj   +1 more source

Universal In Situ Isotope Exchange Raman Spectroscopy (IERS) Methodology for Measuring Oxygen Surface Exchange Dynamics Using a Probe Layer

open access: yesAdvanced Functional Materials, EarlyView.
A bespoke multilayer thin film configuration has been designed, which overcomes the material dependency of conventional isotope exchange Raman spectroscopy (IERS). This universal IERS methodology is efficient, non‐destructive and provides additional structural information and time resolution, which can be further extended to various isotopic elements ...
Zonghao Shen   +7 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

open access: yesAdvanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv   +10 more
wiley   +1 more source

Joint Control of Radiated and Surface Waves via Space‐Time Coding Metasurfaces

open access: yesAdvanced Functional Materials, EarlyView.
A unified space‐time coding metasurface platform enables simultaneous control of radiated and surface‐confined waves across multiple harmonics. Demonstrated functionalities include multi‐frequency beam shaping; surface‐wave excitation, and hybrid multiplexing.
Zihao Dai   +6 more
wiley   +1 more source

IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2

open access: yesJournal of Immunology Research, 2015
Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin ...
Rong Xu   +6 more
doaj   +1 more source

Effects of tetrahydroaminoacridine on M1 and M2 muscarine receptors

open access: yesNeuroscience Letters, 1988
Tetrahydroaminoacridine (THA) has been reported to improve the memory of persons with Alzheimer's disease, but its mechanism of action is uncertain. We found that clinically effective concentrations, 0.03-0.3 microM, readily inhibit acetylcholinesterase and butyrylcholinesterase from rabbit hippocampal tissue in artificial cerebrospinal fluid (CSF) at ...
B D, Pearce, L T, Potter
openaire   +2 more sources

Home - About - Disclaimer - Privacy