Results 81 to 90 of about 180,585 (312)

Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages.

PLoS Pathogens
Macrophages can undergo M1-like proinflammatory polarization with low oxidative phosphorylation (OXPHOS) and high glycolytic activities or M2-like anti-inflammatory polarization with the opposite metabolic activities.
Yumei Li, Christine Wu, Jiyoung Lee, Qiqi Ning, Juhyeon Lim, Hyungjin Eoh, Sean Wang, Benjamin P Hurrell, Omid Akbari, Jing-Hsiung James Ou   +9 more
doaj   +1 more source

Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems.

PLoS ONE, 2012
Studies on the effect of scopolamine on memory are abundant but so far only regulation of the muscarinic receptor (M1) has been reported. We hypothesized that levels of other cholinergic brain receptors as the nicotinic receptors and the N-methyl-D ...
Soheil Keihan Falsafi, Alev Deli, Harald Höger, Arnold Pollak, Gert Lubec   +4 more
doaj   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction

Nature Communications
Achieving a cure is an urgent need for patients with advanced solid tumors. Here, we discover that oncolytic virus (OV) infection enhances IL-18 receptor expression but fails to increase IL-18 ligand expression.
Zhen Fan, Ying Liu, Xueying Lin, Jifu Zhang, Jiehong Chen, Shiming Yi, Cheng Hu, Xincheng Liu, Cui Guo, Cuiying Xu, Xiaoyu Chen, Xuyan Tian, Xuanming Liang, Yang Liu, Linyi Hu, Shanyu Huang, Li Guo, Wenbo Zhu, Jun Hu, Guangmei Yan, Yuan Lin, Jing Cai, Jiankai Liang   +22 more
doaj   +1 more source

Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity

Cell Reports, 2017
IRF5 is a signature transcription factor that induces M1 macrophage polarization. However, little is known regarding cytosolic proteins that induce IRF5 activation for M1 polarization. Here, we report the interaction between ubiquitin E3 ligase Pellino-1
Donghyun Kim, Ho Lee, Jaemoon Koh, Jae Sung Ko, Bo Ruem Yoon, Yoon Kyung Jeon, Young Min Cho, Tae Han Kim, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang, Kyong Soo Park, Hye Young Kim, Chang Woo Lee, Won-Woo Lee, Doo Hyun Chung   +15 more
doaj   +1 more source

Corrigendum: Striatal dopamine D2-muscarinic acetylcholine M1 receptor-receptor interaction in a model of movement disorders. [PDF]

Front Pharmacol, 2022
Crans RAJ, Wouters E, Valle-León M, Taura J, Massari CM, Fernández-Dueñas V, Stove CP, Ciruela F.   +7 more
europepmc   +1 more source

MAGTWIST: A Magnetically‐Driven Rotary Actuator Using a Traveling‐Wave With Integrated Stiffness Tunability

Advanced Functional Materials, EarlyView.
MAGTWIST: A compact magnetic rotary actuator, enabling smooth, stepless rotation, and on‐demand locking. Inspired by peristalsis, a soft polymer belt generates a traveling‐wave, enabling 270° rotation when heated. Cooling stiffens the belt, locking it in position and enabling it to withstand high loads.
Simon Frieler, Jean‐Paul P.M. de Vries, Sarthak Misra, Venkatasubramanian Kalpathy Venkiteswaran   +3 more
wiley   +1 more source

Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification

Frontiers in Immunology
IntroductionMacrophage activation is closely associated with Acute pancreatitis (AP). We screened and found that Growth factor receptor bound protein 2 (Grb2) is highly expressed in macrophages during AP.
Qinhao Shen, Shuai Wang, Keyan Wu, Liuhui Wang, Weijuan Gong, Guotao Lu, Weiwei Chen, Chenchen Yuan, Bo Tu, Wei Li, Yaodong Wang, Weixuan Yang   +11 more
doaj   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. [PDF]

Cell, 2021
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB.   +47 more
europepmc   +1 more source