Results 201 to 210 of about 14,453 (241)
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Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke
Translational Stroke Research, 2022Methylation of adenosine at N1 position yields N1-methyladenosine (m1A), which is an epitranscriptomic modification that regulates mRNA metabolism. Recent studies showed that altered m1A methylation promotes acute and chronic neurological diseases. We currently evaluated the effect of focal ischemia on cerebral m1A methylome and its machinery.
Anil K Chokkalla +2 more
exaly +3 more sources
m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Cell Reports, 2022 N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Hongseok Ha, Yoon Ki Kim
exaly +3 more sources
Effect of M1a and M1b Category in Metastatic Colorectal Cancer [PDF]
Oncologist, 2014 Abstract Background. In 2009, the American Joint Committee on Cancer version 7 staging system introduced the M1 subclassifications M1a (single metastatic site) and M1b (peritoneal or multiple metastatic sites). The study objectives were to evaluate the prognostic effect of site of metastasis and M1a/b
Hagen F Kennecke +2 more
exaly +3 more sources
N 1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]
Journal of Biochemistry, 2020 AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi +2 more
exaly +3 more sources
Cell Chemical Biology
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
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CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
openaire +2 more sources
, 1987 An examination of the compositional changes in the monetary aggregates M1 and M1A, with a discussion of their behavior in the 1980s and some issues relevant to the possibility of replacing M1 with M1A in the monetary targeting framework.
William T. Gavin, Michael R. Pakko
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Mapping m6A and m1A with mutation signatures
Nature Methods, 2019In two novel RNA modification mapping methods, the authors have engineered RNA enzymes and used the enzyme-mediated mutational signatures to map m6A and m1A at single-nucleotide resolution in mammalian RNA.
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Human Genomics
The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang +9 more
semanticscholar +1 more source
The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang +9 more
semanticscholar +1 more source
Scientific Reports
Colorectal cancer (CRC) is the most common malignancy in the digestive system, with a lower 5-year overall survival rate. There is increasing evidence showing that RNA modification regulators such as m1A, m5C, m6A, and m7G play crucial roles in tumor ...
Hao Wei, Qingsong Luo, Weimin Zhong
semanticscholar +1 more source
Colorectal cancer (CRC) is the most common malignancy in the digestive system, with a lower 5-year overall survival rate. There is increasing evidence showing that RNA modification regulators such as m1A, m5C, m6A, and m7G play crucial roles in tumor ...
Hao Wei, Qingsong Luo, Weimin Zhong
semanticscholar +1 more source
, 2004 This work analyzes, from an empirical standpoint, the information contained in the M1A aggregate in Chile and compares it with other aggregates. The findings reveal that, at least for now, the M1A aggregate does not seem to have particularly valuable information that would make it a better indicator of inflationary pressures within the monetary policy ...
Pablo García,, Rodrigo O. Valdés
openaire