Results 191 to 200 of about 26,465 (226)

Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer. [PDF]

Cell Mol Life Sci
Feng Y, He X, Guo M, Tang Y, Qi G, Huang Q, Ma W, Chen H, Qin Y, Li R, Wang J, Liu Y.   +11 more
europepmc   +1 more source

Utilizing tumor deposit count as a stratification criterion in revising TNM staging system for patients with colorectal cancer: a nomogram review study. [PDF]

Front Oncol
Zhang L, Ma Y, Dong J, Cai J.
europepmc   +1 more source

Systematic Pan-Cancer Analysis Identifies PHF6 as an Immunological and Prognostic Biomarker. [PDF]

Diagnostics (Basel)
Tao Y, Hu M, Guo Z, Xu Q, Niu L, Mao Y, Yuan G.   +6 more
europepmc   +1 more source

Overall survival and progression-free survival of patients with non-small cell lung cancer and either limited or extensive synchronous metastatic spread in Germany-a population-based cancer registry cohort study. [PDF]

Transl Lung Cancer Res
Bertram S, Schliemann A, Katalinic A, Kim-Wanner SZ, Pritzkuleit R, Twardella D, Waldmann A.   +6 more
europepmc   +1 more source

Advances in Quantitative Techniques for Mapping RNA Modifications. [PDF]

Life (Basel)
Tian L, Vallabhaneni B, Chang YH.
europepmc   +1 more source

m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation

Cell Reports, 2022
N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Hongseok Ha, Yoon Ki Kim
exaly   +3 more sources

Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m1A-methylated IGF1R [PDF]

Cell Discovery, 2020
AbstractN1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of m1A-methylated messenger RNA (mRNA), but the “reader” protein and the exact biological role of m1A remain to be determined.
Qingliang Zheng
exaly   +3 more sources

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Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke

Translational Stroke Research, 2022
Methylation of adenosine at N1 position yields N1-methyladenosine (m1A), which is an epitranscriptomic modification that regulates mRNA metabolism. Recent studies showed that altered m1A methylation promotes acute and chronic neurological diseases. We currently evaluated the effect of focal ischemia on cerebral m1A methylome and its machinery.
Anil Kiran Chokkalla, Qing Dai, Raghu Vemuganti   +2 more
exaly   +3 more sources

Mo’ m1A, mo’ problems

Cell Chemical Biology
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
openaire   +2 more sources

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Nature, 2017
Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally. Recent studies suggested the widespread presence of N1-methyladenosine (m1A), which disrupts Watson-Crick base pairing, at internal sites of mRNAs. These studies lacked the resolution of identifying individual modified bases, and did not identify specific sequence
Aldema Sas-Chen, Roni Winkler, Aharon Nachshon   +2 more
exaly   +3 more sources