Results 211 to 220 of about 14,453 (241)

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Nature, 2017
Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally. Recent studies suggested the widespread presence of N1-methyladenosine (m1A), which disrupts Watson-Crick base pairing, at internal sites of mRNAs. These studies lacked the resolution of identifying individual modified bases, and did not identify specific sequence
Modi Safra, Aldema Sas-Chen, Ronit Nir, Roni Winkler, Aharon Nachshon, Dan Bar-Yaacov, Matthias Erlacher, Walter Rossmanith, Noam Stern-Ginossar, Schraga Schwartz   +9 more
openaire   +2 more sources

The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation

Angewandte Chemie, 2023
N1-methyladenosine (m1A) is a prevalent post-transcriptional RNA modification, and the distribution and dynamics of the modification play key epitranscriptomic roles in cell development.
Lin Zhang, Hong-Chao Duan, Marcin Paduch, Jin-Jia Hu, Chi Zhang, Yajuan Mu, Houwen Lin, Chuan He, A. Kossiakoff, G. Jia, Liang Zhang   +10 more
semanticscholar   +1 more source

Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications

Expert Reviews in Molecular Medicine
Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms.
Akshat D. Modi, Hira Zahid, A. C. Southerland, Dharmeshkumar M. Modi   +3 more
semanticscholar   +1 more source

Quantitative profiling N1-methyladenosine (m1A) RNA methylation from Oxford nanopore direct RNA sequencing data.

Methods
With the recent advanced direct RNA sequencing technique that proposed by the Oxford Nanopore Technologies, RNA modifications can be detected and profiled in a simple and straightforward manner.
Shenglun Chen, Jia Meng, Yu-xin Zhang
semanticscholar   +1 more source

Elucidating thoracic aortic dissection pathogenesis: The interplay of m1A-related gene expressions and miR-16-5p/YTHDC1 Axis in NLRP3-dependent pyroptosis.

International Journal of Biological Macromolecules
The underlying molecular mechanisms of thoracic aortic dissection (TAD) remain incompletely understood. Recent insights into RNA methylation and microRNA-mediated gene regulation offer new avenues for exploring how these processes contribute to the ...
Kun Liu, Yuemeng Li, Fanxing Yin, Xiaoyu Wu, Xiaoxu Zhang, Deying Jiang, Jian Wang, Zhaoxuan Zhang, Ruihu Wang, Chen Chen, Yanshuo Han   +10 more
semanticscholar   +1 more source

Characterization of the m6A/m1A/m5C/m7G‐related regulators on the prognosis and immune microenvironment of glioma by integrated analysis of scRNA‐seq and bulk RNA‐seq data

Journal of Gene Medicine
Proliferation, metabolism, tumor occurrence and development in gliomas are greatly influenced by RNA modifications. However, no research has integrated the four RNA methylation regulators of m6A, m1A, m5C and m7G in gliomas to analyze their relationship ...
Longkun Yang, Zhicong Huang, Ying Deng, Xing Zhang, Zhonghua Lv, Hao Huang, Qian Sun, Hui Liu, Hongsheng Liang, B. He, Fulan Hu   +10 more
semanticscholar   +1 more source

Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in Streptomyces venezuelae.

ACS Chemical Biology
tRNA modifications help maintain tRNA structure and facilitate translation and stress response. Found in all three kingdoms of life, m1A tRNA modification occurs in the T loop of many tRNAs, stabilizes tertiary tRNA structure, and impacts translation ...
M. Foo, Luke R. Frietze, Behnam Enghiad, Yujie Yuan, Christopher D Katanski, Huimin Zhao, Tao Pan   +6 more
semanticscholar   +1 more source

m1A modification of tRNA in anaplastic thyroid cancer

This project aims to explore the impact of TRMT6/TRMT61A-mediated m1A modification of tRNA on the progression of anaplastic thyroid cancer and its molecular mechanism. The cells used in this study are human anaplastic thyroid cancer cells KHM-5M.
openaire   +1 more source

Toxicological Perspectives on RNA m1A Methylation: Biological Processes and Pathological Consequences

Journal of Applied Toxicology
ABSTRACT RNA N1‐methyladenosine (m1A) methylation is dynamically regulated by methyltransferases (TRMT6/61/61B/10C), demethylases (ALKBH1/3), and binding proteins (YTHDF1/2/3), which collectively fine‐tune gene expression through site‐specific modifications.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
openaire   +2 more sources

The m1A modification of tRNAs: a translational accelerator of T-cell activation

Cellular & Molecular Immunology, 2022
Cheng Chen, Lilin Ye
openaire   +2 more sources