Results 101 to 110 of about 2,157,910 (222)

Effect of inflammatory cell mediators on M2 muscarinic receptors in the lungs

Life Sciences, 1993
Acetylcholine released from vagal nerve endings constricts airways by stimulating M3 muscarinic receptors on the airway smooth muscle. At the same time, released acetylcholine feeds back onto inhibitory M2 muscarinic autoreceptors on the nerve endings, limiting further release of acetylcholine.
A D, Fryer, D B, Jacoby
openaire   +2 more sources

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Anti-M2 muscarinic receptor antibodies inhibit beta-adrenoceptor-mediated inotropic response in rat myocardium

, 1997
The modulation of the inotropic effect by affinity-purified antibodies against a synthetic peptide corresponding to the second extracellular loop of the human muscarinic M2 receptors was studied in adult rat ventricular myocardium.
Hjalmarson, Åke,, Hoebeke, Johan, Skomedal, T, Osnes, J B, Fu, Michael,, Schiander, I G   +5 more
core  

Modifying Muscarinic Signaling through Mutation of the Neurotransmitter Receptor M2\u27s G-Protein

, 2013
Muscarinic receptors are a class of G-protein-coupled receptors which recognize Acetylcholine to activate three main signaling systems. The path that the signal follows is determined by the G-protein with which the receptor communicates.
Frye, Hannah
core   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover

, 1987
To investigate whether a particular receptor subtype can be coupled to multiple effector systems, recombinant M2 muscarinic receptors were expressed in cells lacking endogenous receptor.
Capon, D. J., Schimerlik, M. I., Ramachandran, J., Winslow, J. W., Peterson, G. L., Ashkenazi, A., Peralta, E. G., Gary L. Peterson, Avi Ashkenazi, Ernest G. Peralta, Michael I. Schimerlik, Daniel J. Capon, John W. Winslow, Janakiraman Ramachandran   +13 more
core   +1 more source

Early hypersalivation as a risk marker for inflammatory adverse reactions to clozapine

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Kazusa Miyahara, Takuto Ishida, Hiroyasu Ino, Akihiko Nunomura   +3 more
wiley   +1 more source

Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]

, 2000
The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Haga, T., Furukawa, H.
core   +1 more source

Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M2 and M3 Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal

Cellular Physiology and Biochemistry, 2017
Background: Magnolia officinalis Rehder and EH Wilson (M. officinalis) are traditional Chinese medicines widely used for gastrointestinal (GI) tract motility disorder in Asian countries. We investigated the effects of an ethanol extract of M. officinalis
Hyun Jung Kim, Taewon Han, Yun Tai Kim, Insuk So, Byung Joo Kim   +4 more
doaj   +1 more source

M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition. [PDF]

Cancers (Basel), 2023
Guerriero C, Manfredelli M, Matera C, Iuzzolino A, Conti L, Dallanoce C, De Amici M, Trisciuoglio D, Tata AM.   +8 more
europepmc   +1 more source