Results 121 to 130 of about 2,157,910 (222)

RGS3L allows for an M₂ muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes. [PDF]

Basic Res Cardiol, 2022
Levay MK, Krobert KA, Vogt A, Ahmad A, Jungmann A, Neuber C, Pasch S, Hansen A, Müller OJ, Lutz S, Wieland T.   +10 more
europepmc   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Voltage dependence of M2 muscarinic receptor antagonists and allosteric modulators

Biochemical Pharmacology
Muscarinic receptors are G protein-coupled receptors (GPCRs) that play a role in various physiological functions. Previous studies have shown that these receptors, along with other GPCRs, are voltage-sensitive; both their affinity toward agonists and their activation are regulated by membrane potential.
Shimrit, Hazan, Merav, Tauber, Yair, Ben-Chaim   +2 more
openaire   +2 more sources

67 | DYNAMICS AND INTRACELLULAR TRAFFICKING OF M2R-DUALSTERIC AGONIST COMPLEX INTO GLIOBLASTOMA CELLS

European Journal of Histochemistry
The M2 muscarinic receptor is a typical G protein–coupled receptors with inhibitory properties. Behind its canonically physiological role in the nervous system, previous studies demonstrated that its selective activation causes inhibitory effects in ...
GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
doaj   +1 more source

Primary structure and biochemical properties of an M2 muscarinic receptor

, 1987
A partial amino acid sequence obtained for porcine atrial muscarinic acetylcholine receptor was used to isolate complementary DNA clones containing the complete receptor coding region.
Smith, D. H., Capon, D. J., Schimerlik, M. I., Ramachandran, J., Winslow, J. W., Peterson, G. L., Ashkenazi, A., Peralta, E. G., J. Ramachandran, Douglas H. Smith, Gary L. Peterson, Avi Ashkenazi, Ernest G. Peralta, Michael I. Schimerlik, Daniel J. Capon, John W. Winslow   +15 more
core   +1 more source

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in Saccharomyces cerevisiae

Microbial Cell
Glioblastoma is a malignant astrocytic tumor of the brain. A significantly decrease of glioblastoma cell proliferation and survival can be achieved by activating the M2 muscarinic acetylcholine receptor (a G protein-coupled receptor, or GPCR) with two ...
Angela Cirigliano, Antonia Amelina, Elena Passarini, Alessandra Ricelli, Nicole Balasco, Mattia Mori, Bruno Botta, Maria Egle De Stefano, Claudio Papotto, Claudia Guerriero, Ada Maria Tata, Teresa Rinaldi   +11 more
doaj   +1 more source

Active immunization of combined beta1-adrenoceptor and M2-muscarinic receptor peptides induces cardiac hypertrophy in rabbits

, 1999
BACKGROUND: The high prevalence of patients with dilated cardiomyopathy (DCM) with anti-beta1-adrenoceptor and/or anti-M2-muscarinic receptor autoantibodies in their sera has been observed.
Matsui, S, Kurihara, T, Teraoka, K, Yamaguchi, N, Hayase, M, Fu, Michael,, Takekoshi, N, Katsuda, S   +7 more
core  

The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells. [PDF]

Int J Mol Sci, 2020
Lucianò AM, Perciballi E, Fiore M, Del Bufalo D, Tata AM.   +4 more
europepmc   +1 more source

Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function

, 1994
The effect of acute ozone exposure on the function of efferent parasympathetic nerves, M3 muscarinic receptors on airway smooth muscle, and inhibitory M2 muscarinic receptors on the parasympathetic nerves was studied.
A. H. Schultheis, D. J. Bassett, A. D. Fryer   +2 more
core   +1 more source

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. [PDF]

Nature, 2020
Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G.   +8 more
europepmc   +1 more source