Results 111 to 120 of about 2,157,910 (222)

Transcriptional regulation of the human muscarinic M2 receptor gene [PDF]

, 2003
Muscarinic M2 receptors are important regulators of airway smooth muscle tone and alteration in M2 receptor function has been described in asthmatic patients.
Swan, Caroline, Billington, Charlotte K., Richards, Susan, Felice, Alex E., Ellul-Micallef, Roger, Hunter, Therese, Ebejer, Martin J., Fenech, Anthony G.   +7 more
core  

M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors. [PDF]

Function (Oxf), 2022
Alkawadri T, Wong PY, Fong Z, Lundy FT, McGarvey LP, Hollywood MA, Thornbury KD, Sergeant GP.   +7 more
europepmc   +1 more source

Transforming growth factor-β1 induces transcriptional down-regulation of m2 muscarinic receptor gene expression

, 1996
In human embryonic lung fibroblasts, transforming growth factor-β1 (TGF- β1) induced a time-dependent down-regulation of M2 muscarinic receptor binding sites as measured with the nonselective hydrophilic ligand [2H]N- methylscopolamine (NMS).
Barnes, PJ, Rousell, J, Mak, JCW, Haddad, EB   +3 more
core  

Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients

Cardiology Research and Practice, 2019
Objectives. To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods.
Guiling Ma, Xuejiao Wu, Lijun Zeng, Jiawei Jin, Xingpeng Liu, Jianjun Zhang, Lin Zhang   +6 more
doaj   +1 more source

M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines. [PDF]

Cells, 2021
Di Bari M, Tombolillo V, Alessandrini F, Guerriero C, Fiore M, Asteriti IA, Castigli E, Sciaccaluga M, Guarguaglini G, Degrassi F, Tata AM.   +10 more
europepmc   +1 more source

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
NOJYO, Yoshiaki, IINO, Satoshi
core  

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor

, 2013
Background and Purpose Artificial agonists may have higher efficacy for receptor activation than the physiological agonist. Until now, such 'superagonism' has rarely been reported for GPCRs. Iperoxo is an extremely potent muscarinic receptor agonist.
E. Kostenis, K. Mohr, M. De Amici, J. Klöckner, C. Dallanoce, U. Holzgrabe, R. Schrage, W. K. Seemann, K. Racké   +8 more
core   +1 more source

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

Doberman pinschers under study: Basic characteristics and serum activities of autoantibodies directed against the β1-adrenergic (β1-AAB) and muscarinic receptor 2 (M2-AAB).

, 2019
Doberman pinschers under study: Basic characteristics and serum activities of autoantibodies directed against the β1-adrenergic (β1-AAB) and muscarinic receptor 2 (M2-AAB).
Anna Fritscher (6919454), Katrin Wenzel (252624), Niels-Peter Becker (6919457), Johannes Müller (79127), Gerhard Wess (220330), Gerd Wallukat (252625), Ingolf Schimke (2204113)   +6 more
core   +1 more source