Results 131 to 140 of about 13,431 (216)

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

Scientific Reports
Target identification is a crucial step in elucidating the mechanisms by which functional food components exert their functions. Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid ...
Chisato Tanaka, Naoki Harada, Yoshiaki Teraoka, Hiroki Urushizaki, Yoh Shinmori, Teruaki Onishi, Yusuke Yotsumoto, Yuta Ito, Tomoya Kitakaze, Takashi Inui, Yuji Murata, Hiroshi Inui, Ryoichi Yamaji   +12 more
doaj   +1 more source

Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors. [PDF]

, 2011
BACKGROUND: Enteric neurotransmitters that act at G protein-coupled receptors (GPCRs) are well known to acutely promote epithelial Cl(-) and fluid secretion.
Bertelsen, Lone S, Frankson, Michelle, Keely, Stephen J, Kelly, Orlaith B, Mroz, Magdalena S, Toumi, Ferial, Ward, Joseph B   +6 more
core   +1 more source

The relaxant effect of Ferula assafoetida on smooth muscles and the possible mechanisms [PDF]

, 2015
Asafoetida (Ferula asafoetida) an oleo-gum-resin belongs to the Apiaceae family which obtained from the living underground rhizome or tap roots of the plant. F.
Boskabady, M.H., Khazdair, M.R.
core  

Muscarinic acetylcholine receptor M3 (CHRM3; HM3) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Understanding the Muscarinic Acetylcholine M3 Receptor: Structure, Function, and Therapeutic Implications

International Journal of Biomedical Science
Muscarinic acetylcholine M receptors (mAChRs) belong to the G protein-coupled receptor (GPCR) superfamily and play a crucial role in regulating and controlling the release of acetylcholine (ACh). This review aims to focus on M3 receptor (M3R) subtype distribution, function, efficacy, and clinical applications.
Shi-wan-er Chen, Jie Wu
openaire   +1 more source

Muscarinic acetylcholine receptor M3 (CHRM3; HM3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Ligand-Induced Activation of the M3-Muscarinic Acetylcholine Receptor

This thesis explores the computer-aided drug design of the M3-muscarinic acetylcholine receptor in three chapters. The first chapter focuses on molecular docking to identify novel agonists using the ZINC12 library. A model of the M3 receptor was built based on the M2 receptor.
openaire   +1 more source

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]

, 2020
Chess-Williams, Russ, McDermott, Catherine, Sellers, Donna J, West, Eliza   +3 more
core   +1 more source