Results 111 to 120 of about 7,801 (240)

Pharmacological investigations on muscarinic and P2 receptor subtypes : pharmacological charakterisation of the stereoisomers of glycopyrronium bromide and their tertiary analogues and evaluation of the isolated guinea-pig and rat ileal longitudinal

, 2003
Die Beschäftigung mit Muskarinrezeptoren reicht bis in das vergangene Jahrhundert zurück als, in Folge der verschiedenen Wirkungen des Neurotransmitters Acetylcholin, einerseits Nikotin- und andererseits Muskarinrezeptoren sowie deren Subtypen entdeckt ...
Czeche, Sittah
core  

Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells

, 2009
Acetylcholine is the primary parasympathetic neurotransmitter in the airways and is known to cause bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine also regulates aspects of remodelling and inflammation through its ...
Ninaber, D. K., Kolahian, S., Gosens, R., Hiemstra, P. S., Halayko, A. J., Meurs, H., Rabe, K. F., Zuyderduyn, S., Rieks, D., Nanninga, J.   +9 more
core   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cancer Cell International, 2018
Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu, Bingyuan Zhang   +9 more
doaj   +1 more source

MUSCARINIC M1 AND M3 RECEPTOR GENE EXPRESSION DURING PANCREATIC REGENERATION AND INSULIN SECRETION IN RATS

, 2003
The present work is an attempt to understand the role of acetylcholine muscarinic M1 and M3 receptors during pancreatic regeneration and insulin secretion. The work focuses on the changes in the muscarinic M1 and M3 receptors in brain and pancreas during
Paulose,C S, Renuka, T R
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functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

, 2014
Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile.
Vladimir Wsol, Killi, Uday Kumar, Tobin, Gunnar,, Soukup, Ondrej, Michael Winder, Uday K Killi, Winder, Michael,, Wsol, Vladimir, Kuca, Kamil, Ondrej Soukup, Kamil Kuca, Gunnar Tobin   +11 more
core   +1 more source

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

The Journal of Clinical Hypertension
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP).
Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu   +22 more
doaj   +1 more source

Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives

Frontiers in Molecular Biosciences
Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through the trabecular meshwork. While FDA-approved M3
Minjae J. Kim, Mohamed M. Ibrahim, Mohamed M. Ibrahim, Monica M. Jablonski, Monica M. Jablonski   +4 more
doaj   +1 more source

Effect of Eugenol on Detrusor Muscle: Potential for Overactive Bladder Treatment [PDF]

International Neurourology Journal
Purpose This investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches. Methods To assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue,
Marília Cavalcante Araújo, Átila Pereira-Gonçalves, André Nogueira Cardeal dos Santos, José Ednésio da Cruz Freire, Luís Peireira-de-Morais, Francisco Sydney Henrique-Félix, Nicoly Câmara Castro Sousa-Júlio, José Henrique Leal-Cardoso, Andrelina Noronha Coelho-de-Souza   +8 more
doaj   +1 more source

Acetylcholine-treated murine dendritic cells promote inflammatory lung injury.

PLoS ONE, 2019
In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Soledad Gori, Julieta Alcain, Silvia Vanzulli, Mariela A Moreno Ayala, Marianela Candolfi, Carolina Jancic, Jorge Geffner, Mónica Vermeulen, Gabriela Salamone   +8 more
doaj   +1 more source