Results 91 to 100 of about 7,801 (240)

The Potential of Active Compounds from Melinjo Leaves (Gnetum gnemon) as an Antihistamine using Molecular Docking Approach for Acetylcholine Muscarinic M3 Receptor Inhibition

, 2023
Melinjo leaves (Gnetum gnemon) have been used traditionally in Maluku to treat spoilage in the fish product. Melinjo leaves contain secondary metabolites with anti-inflammatory and antibacterial biological activities.
Gaspersz, Nelson, Amos, Matthew Adi Honey, Sohilait, Mario R., Baharudin, Muh. Daswar A., Herland Satriawan, Pattiasina, Priska M., El, Rahma, Male, Yusthinus T., Leuwol, Dean Y.E.   +8 more
core   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
core   +1 more source

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis

BMC Gastroenterology, 2010
Background Autoantibodies to the human muscarinic acetylcholine receptor of the M3 type (hmAchR M3) have been suggested to play an etiopathogenic role in Sjögren's syndrome.
Berg Peter A, Gregor Michael, Lauber Kirsten, Blume Karin, Berg Christoph P, Wesselborg Sebastian, Stein Gerburg M   +6 more
doaj   +1 more source

Multi‐Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders

Aging Cell, Volume 25, Issue 5, May 2026.
Integrating large‐scale human snRNA‐seq, spatial transcriptomics, and cerebral organoid datasets reveals cell‐type‐specific neurotransmitter‐system remodeling across aging and CNS disorders. Shared and disease‐specific NTS alterations highlight candidate mechanisms, sex differences, and exploratory discriminatory signals that may guide mechanistic ...
Rui‐Ze Niu, Meng‐Yuan Zhang, Yan‐Ping Li, Xiao‐Qian Zhou, Xiao‐Lei Liu, Jie Wu, Wei‐Wei Wang, Yan‐Jun Wang, Yi Ruan, Yu Ding, Xiao‐Feng Zeng, Tian‐Hao Bao   +11 more
wiley   +1 more source

Signaling Bias and Antagonism of Pilocarpine for M3 Muscarinic Acetylcholine Receptor

The FASEB Journal, 2018
Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth since the 19 th century and classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with its main therapeutic target ‐ muscarinic M3 receptor ...
Alexey N. Pronin, Kelly Wang, Vladlen Z. Slepak   +2 more
openaire   +1 more source

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
NOJYO, Yoshiaki, IINO, Satoshi
core   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms

Frontiers in Cellular Neuroscience, 2019
In hippocampal CA1, muscarinic acetylcholine (ACh) receptor (mAChR) activation via exogenous application of cholinergic agonists has been shown to presynaptically inhibit Schaffer collateral (SC) glutamatergic inputs in stratum radiatum (SR), and ...
Priyodarshan Goswamee, A. Rory McQuiston
doaj   +1 more source

a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist

, 2020
Previous work from our laboratory indicates that bile acids, specifically lithocholic acid conjugates, interact with muscarinic receptors on gastric chief cells.
Kunrong Cheng, Richard H Kennedy, Piotr Zimniak, Ying Chen, Jean-Pierre Raufman, Sandeep Khurana   +5 more
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