Results 101 to 110 of about 7,801 (240)

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, Volume 74, Issue 5, Page 1314-1325, May 2026.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

The molecular basis of V2 vasopressin receptor-G Protein coupling selectivity

, 2003
G­Protein­gekoppelte Rezeptoren (GPCRs) stellen eine der größten in der Natur vorkommenden Proteinfamilien dar (Watson and Arkinstall, 1994). GPCRs sind plasmamembranständige Proteine, die mit heterotrimären G­Proteinen interagieren und eine Vielzahl an ...
Erlenbach, Isolde
core  

EA increased acetylcholine production and muscarinic acetylcholine receptor expression in the cerebral cortex.

, 2013
(A) Acetylcholine levels in the cerebral cortex 20 min after the end of EA stimulation were analyzed by ELISA.
Sun Sik Bae (284124), Kyung Ha Choi (284122), Young Jung Jang (284123), Hwa Kyoung Shin (284125), Ji Hyun Kim (284121), Byung-Cheul Shin (128397), Byung Tae Choi (226842)   +6 more
core   +1 more source

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Claudia Guerriero, Chiara De Nuccio, Maria Petrone, Teresa Rinaldi, Angela Cirigliano, Sergio Visentin, Antonietta Bernardo, Luciano Conti, Carlo Matera, Marco De Amici, Clelia Dallanoce, Ada Maria Tata   +11 more
wiley   +1 more source

Effect of the ligand in the Modeling the 3d structure of the m3 muscarinic receptor [PDF]

, 2013
There are still many question open to completely understand the structure-activity relationships of G-protein coupled receptors. Issues like the actual mapping of the binding site of different subtypes, as well as the mechanism of activation are poorly ...
Rasaeifar, Bahareh
core   +1 more source

A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

, 2006
SummaryOne of the hallmarks of type 2 diabetes is that pancreatic β cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels.
Li, Jian Hua, Mears, David, Li, Bo, Han, Sung-Jun, Lu, Huiyan, Heard, Thomas, Wess, Jürgen, Gautam, Dinesh, Cui, Yinghong, Deng, Chuxia, Jeon, Jongrye, Hamdan, Fadi F.   +11 more
core   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source

M3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells

, 1993
This study was designed to characterize the muscarinic acetylcholine receptor (mAChR) subtype present in rat exorbital lacrimal gland as well as its biochemical coupling.
P. Mauduit, H. Jammes, B. Rossignol
core   +1 more source

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo, Huan Chen, Ali Wu, Weipu Mao, Sagar Barge, Seth L. Alper, Simon C. Robson, Weiqun Yu   +7 more
wiley   +1 more source

Desensitization of the m3-muscarinic acetylcholine-receptor in the smooth muscle and the intracellular signal transduction.

Folia Pharmacologica Japonica, 1994
Desensitization of the m3-muscarinic acetylcholine-receptor in the smooth muscle of the digestive tract is discussed together with the changes in intracellular signal transduction. Isolated single cells that show an all-or-none contractile response to acetylcholine were desensitized by treatment with 0.1 mM acetylcholine for 10 min, resulting in an ...
M K, Uchida, M, Mita, K, Oishi, S, Hishinuma   +3 more
openaire   +3 more sources