Results 81 to 90 of about 7,801 (240)

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj   +1 more source

Acetylcholine Receptor Stimulation Activates Protein Kinase C Mediated Internalization of the Dopamine Transporter

Frontiers in Cellular Neuroscience, 2021
The dopamine transporter (DAT) clears neurotransmitters from the extracellular space and serves as an important regulator of signal amplitude and duration at sites of dopamine release. Several different intracellular signaling pathways have been observed
Suzanne M. Underhill, Susan G. Amara
doaj   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity

Journal of Pharmaceutical Analysis, 2021
Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs.
Blessing O. Omolaso, Francis S. Oluwole, Olugbenga A. Odukanmi, Julius K. Adesanwo, Ahmed A. Ishola, Kayode E. Adewole   +5 more
doaj   +1 more source

Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
A new computational method and analytical pipeline for quantifying gut peristalsis in live mouse models that involves taking a video using a smartphone camera and then processing the videographic data using our custom analytical pipeline to quantify gastrointestinal motility.
Joseph C. Schindler, Gargi Vijayan Pillai, Thomas M. Raffay, Satish E. Viswanath, Puneet Seth   +4 more
wiley   +1 more source

Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens

Animals
Photoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Miao Yu, Mengjie Xu, Guangju Wang, Jinghai Feng, Minhong Zhang   +4 more
doaj   +1 more source

Influence of nano-TiO2 on functioning of gastric smooth muscles: in vitro and in silico studies

Біологічні студії, 2019
Nanosized materials, including titanium dioxide nanoparticles, sized under 10 nm, are systems with an excessive energy and high chemical activity, while the nanopartic­les of about (1–3) nm enter the reactions with other chemical compounds practically ...
O. V. Tsymbalyuk, A. M. Naumenko, T. L. Davydovska   +2 more
doaj   +1 more source

Muscarinic receptor activation in colon cancer selectively augments pro-proliferative microRNA-21, microRNA-221 and microRNA-222 expression.

PLoS ONE, 2022
Overexpression of M3 subtype muscarinic receptors (M3R) hastens colon cancer progression. As microRNA (miRNA) expression is commonly dysregulated in cancer, we used microarrays to examine miRNA profiles in muscarinic receptor agonist-treated human colon ...
Shannon M Larabee, Kunrong Cheng, Jean-Pierre Raufman, Shien Hu   +3 more
doaj   +1 more source

Parasympathetic overdrive as a cause of overactive bladder in a high‐fat‐diet‐induced obesity mouse model

The Journal of Physiology, Volume 604, Issue 12, Page 4945-4967, 15 June 2026.
Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +3 more
wiley   +1 more source

M3 Muscarinic Acetylcholine Receptor-Mediated Signaling Is Regulated by Distinct Mechanisms

Molecular Pharmacology, 2008
We have used RNA interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates endogenously expressed H1 histamine receptor in human embryonic kidney 293 cells. In this report, we investigate the regulation of endogenously expressed M(3) muscarinic acetylcholine receptor (M(3) mAChR).
Jiansong, Luo, John M, Busillo, Jeffrey L, Benovic   +2 more
openaire   +3 more sources