Results 211 to 220 of about 7,801 (240)

m3 Muscarinic Acetylcholine Receptor Regulation in the Airway

American Journal of Respiratory Cell and Molecular Biology, 2002
The m3 muscarinic acetylcholine receptor (m3 mAChR) plays an important role in airway function by mediating the effects of acetylcholine on multiple airway cell types. m3 mAChRs expressed in airway smooth muscle (ASM) cells promote increased ASM tension, and, therefore, airway narrowing, in response to acetylcholine release from postganglionic ...
Charlotte K, Billington, Raymond B, Penn
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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

Nature, 2001
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult primarily because of a lack of ...
M, Yamada, T, Miyakawa, A, Duttaroy, A, Yamanaka, T, Moriguchi, R, Makita, M, Ogawa, C J, Chou, B, Xia, J N, Crawley, C C, Felder, C X, Deng, J, Wess   +12 more
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Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility

Digestive Diseases and Sciences, 2022
The specific role of the M3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds.The objective of this study was to determine the region-specific role of the M3 receptor in gastrointestinal motility.We developed a novel positive allosteric modulator (PAM ...
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa   +10 more
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Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells

Hepatobiliary & Pancreatic Diseases International, 2012
Cholangiocarcinoma, a type of malignant tumor, originates from epithelial cells of the bile duct. Perineural invasion is common path for cholangiocarcinoma metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It has been reported that muscarinic acetylcholine receptor M3 (mAChR M3) is widely expressed in digestive ...
Yu-Jie, Feng, Bing-Yuan, Zhang, Ru-Yong, Yao, Yun, Lu   +3 more
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Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren’s syndrome

Modern Rheumatology, 2012
Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. Recently, autoantibodies against muscarinic acetylcholine receptor M3 (M3R) have been detected in serum from 9 to 100 % of patients with SS in addition to anti-SS-A and anti-SS-B antibodies.
Takayuki, Sumida, Hiroto, Tsuboi, Mana, Iizuka, Hiromitsu, Asashima, Isao, Matsumoto   +4 more
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Cloning and expression of a cDNA encoding bovine muscarinic acetylcholine m3 receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994
A cDNA clone encoding bovine muscarinic acetylcholine m3 receptor has been isolated from a bovine brain library. Sequencing of this clone has revealed a single open reading frame encoding a protein of 590 amino acids. Comparison with known muscarinic m3 receptor sequences from other species shows a high degree of conservation (92-98% homology) in the ...
P H, Lee, P K, Hodges, F, Glickman, K J, Chang   +3 more
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Identification of a novel protein partner of the M3 muscarinic acetylcholine receptor

The FASEB Journal, 2008
The M 3 muscarinic acetylcholine receptor is widely expressed throughout the central nervous system and is also found in many peripheral tissues and cell types. Several lines of work suggest that drugs acting on central or peripheral M 3 receptors might
Rosemond E, SCARSELLI, MARCO, De Azua I. Ruiz, Wess J.   +3 more
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Interaction of Edrophonium with Muscarinic Acetylcholine M2and M3Receptors

Anesthesiology, 2001
Background It has been reported that edrophonium can antagonize the negative chronotropic effect of carbachol. This study was undertaken to evaluate in detail the interaction of edrophonium with muscarinic Mz and M3 receptors. Methods A functional study was conducted to evaluate the
Y, Tanito, T, Miwa, M, Endou, Y, Hirose, M, Gamoh, H, Nakaya, F, Okumura   +6 more
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M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines

Bioorganic & Medicinal Chemistry Letters, 2009
Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M(3) muscarinic acetylcholine receptor antagonists such as 14 (pA(2)=11.0) possessing good sub-type selectivity for M(3) over M(2). The structure-activity relationships (SAR) and optimization of the bi-aryl amine series are described.
Brian, Budzik, Yonghui, Wang, Dongchuan, Shi, Feng, Wang, Haibo, Xie, Zehong, Wan, Chongye, Zhu, James J, Foley, Parvathi, Nuthulaganti, Lorena A, Kallal, Henry M, Sarau, Dwight M, Morrow, Michael L, Moore, Ralph A, Rivero, Michael, Palovich, Michael, Salmon, Kristen E, Belmonte, Dramane I, Laine, Jian, Jin   +18 more
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Role of microtubule structure in the maintenance of m3-muscarinic acetylcholine receptor rnRNA levels

Molecular and Cellular Neuroscience, 1991
The regulation of m3-muscarinic acetylcholine receptor (mAChR) mRNA following exposure to microtubule-disrupting agents was studied in cultured cerebellar granule cells. Colchicine (10 muM), an antimicrotubular agent, decreased the levels of m3-mAChR mRNA in a time-dependent fashion.
F, Fukamauchi, C, Hough, D M, Chuang
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