Results 61 to 70 of about 4,436 (138)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of reduced graphene oxide on mechanical properties of concrete [PDF]

EPJ Web of Conferences
M40 grade concrete’s balanced strength and endurance make it a popular choice for structural applications. The usage of nanoparticles to enhance the characteristics of conventional concrete has increased recently due to the need for high-performance and ...
Khanapuram Anand Goud, Sunkoji Navaneeth Kumar, Pamu Yashwanth   +2 more
doaj   +1 more source

An Interpretable Deep Learning Model for Detecting Tropical Cyclone Genesis Through Incorporation of the Dynamic and Thermodynamic Environment

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 3, June 2026.
Abstract In recent decades, tropical cyclone (TC) track forecasting has improved significantly. However, prediction of TC genesis (TCG) remains challenging. Accurate prediction of TCG is critical for disaster prevention and mitigation. This study develops an interpretable deep learning model that integrates 3D‐residual blocks with gated recurrent units
Kaiji Liu, Haikun Zhao, Philip J. Klotzbach, Zhanhong Ma, Chunyi Xiang, Wei Zhong, Wei Tian, Liguang Wu   +7 more
wiley   +1 more source

Have COVID-19 and the War in Ukraine Caused a Decline in the Value Relevance of Accounting Information? Evidence from Poland

Folia Oeconomica Stetinensia
Within the research area of value relevance (VR), the impact of macroeconomic changes is usually analysed. The influence of economic crises, such as the Asian financial crisis, global financial crisis, and COVID-19, on VR was, however, inconclusive ...
Pilch Bartłomiej
doaj   +1 more source

Home Safe Home: Safety Gains Through Telework During the Covid‐19 Pandemic

LABOUR, Volume 40, Issue 2, Page 162-192, June 2026.
ABSTRACT This paper exploits exogenous shifts in work organisation during the Covid‐19 pandemic to study the implications of hybrid and remote work arrangements on occupational safety. Combining accident registers and household survey microdata from Hungary, we are able to address potential selection and reporting bias, and reliably identify the ...
Bálint Menyhért, Szilárd Erhart
wiley   +1 more source

Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Saquayamycin B1 (SQ‐B1), an antibiotic isolated from Streptomyces sp. I072, triggers cell death in different melanoma cell lines, including chemoresistant SK‐MEL‐5. SQ‐B1 elevates O2•‐ and NO• on both sides of the membrane and blocks glutathione transferase (GSTP‐1) and glutathione reductase (GSR), destabilizing the GSH/GSSG antioxidant system.
Geovana Guedes Silvestre, Thalisson Amorim de Souza, Alan Ferreira Alves, Valeria Dutan‐Patiño, Jean‐Michel Huvelin, Mathilde Gourdel, Mikael Croyal, Samuel Cibulski, Demetrius Antonio Machado de Araújo, Marcus Tullius Scotti, Josean Fechine Tavares, Angela Tesse, El‐Hassan Nazih, Marianna Vieira Sobral   +13 more
wiley   +1 more source

A Biochar‐Based Composite Hydrogel Microenvironment for Enhanced Biocatalysis

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
This work presents the synthesis of a polyacrylamide hydrogel wherein biomass‐derived biochar is co‐encapsulated with the enzyme horseradish peroxidase (HRP). The resulting composite hydrogel possesses balanced electron‐rich and electron‐deficient domains, creating an optimal microenvironment that concentrates both hydrogen peroxide and phenol ...
Shengzhe Wang, Jingling Zhu, Weiyang Xue, Yuting Wen, Zhongxing Zhang, Xia Song, Yuan Yu, Chenglin Sun, Huangzhao Wei, Jun Li   +9 more
wiley   +1 more source

Effects of Different Stocking Density on the Growth Performance, Digestive Enzyme Activities, Non-Specific Immunity and Anti-Stress Ability of Lateolabrax japonicus [PDF]

Progress in Fishery Sciences
Studies on the stocking density of Japanese seabass (Lateolabrax japonicus) are limited. In addition, most studies have been mainly conducted in small laboratory water bodies, industrial cement ponds, and soil ponds, with few studies on seawater cages ...
WANG Chengqiang, XIANG Zhiwei, LI Baoshan, WANG Xiaoyan, HAO Tiantian, SONG Zhidong, SUN Yongzhi, LI Peiyu, LI Lu, HUANG Bingshan, CAO Tihong   +10 more
doaj   +1 more source

FROM PLANT GENOMES TO PROTEIN FAMILIES: COMPUTATIONAL TOOLS

Computational and Structural Biotechnology Journal, 2013
The development of new high-throughput sequencing technologies has increased dramatically the number of successful genomic projects. Thus, draft genomic sequences of more than 60 plant species are currently available.
Manuel Martinez
doaj   +1 more source

A-Reits Value Relevance of Performance Measures: Net Income, Funds from Operations and Fair Value of Investment Property

Real Estate Management and Valuation
This study investigates value relevance of three-performance measures (net income (NI), funds from operations (FFO), and fair values on investment property (FVIP) on stock prices of Australian Real Estate Investment Trusts (A-REITs).
Sarpong-Oti William, Gholipour Hassan F., Marzuki Jufri, Chege Fredrick   +3 more
doaj   +1 more source