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Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches. [PDF]

ChemMedChem
This paper by Kollár et al. reports a covalent fragment linking study against the SARS‐CoV‐2 main protease (3CLPro). Beginning with inactive fragment hits, the application of rational linker design enabled the generation of reversible covalent inhibitors exhibiting low micromolar potency. The study details some general limitations and best practices of
Kollár L, Mihalovits LM, Bajusz D, Knez D, Simon J, Balcomb BH, Fearon D, Gobec S, Keserű GM.   +8 more
europepmc   +2 more sources

Potential SLA Hp-4.0 haplotype-restricted CTL epitopes identified from the membrane protein of PRRSV induce cell immune responses [PDF]

Frontiers in Microbiology
Swine leukocyte antigen (SLA) class I molecule-restricted T-cell epitopes, which induce cytotoxic T lymphocyte (CTL) responses, play a critical role in the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) and the development of ...
Tingyu Luo, Chang Xin, Hongyi Liu, Changwen Li, Hongyan Chen, Changyou Xia, Caixia Gao   +6 more
doaj   +2 more sources

Autonomy Without Accountability in Resource Allocation Reforms: Blending Old and New Logic in Universities

Central European Management Journal, 2022
Purpose: The article explores changes in the institutional autonomy and accountability resulting from university reforms carried out over a period of 28 years under the influence of the traditional public administration and new public management logic.
Górska Anna, Pikos Anna, Dobija Dorota, Grossi Giuseppe   +3 more
doaj   +1 more source

Economic Motives and Willingness of Young People to Participate in Fraud

Naše Gospodarstvo, 2022
Fraud is linked to economic and financial pressures that force people to commit it. Any fraud, regardless of the gender and age of the fraud perpetrators, inevitably leaves a short-term or long-term negative mark on society’s economy.
Dimitrijević Dragomir, Jovanović Dejan
doaj   +1 more source

Grouping of Major Changes in Conceptual Framework of Financial Reporting and Analysis of New Challenges

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2021
This article aims to research the major changes in the Conceptual Framework of Financial Reporting; to find out the new gaps in the current document; to group the changes into categories; to analyze the current difficulties and consequences of these ...
Shkulipa Liudmyla
doaj   +1 more source

Knowledge of Network-Based Market Orientation for the Internationalization of Disruptive Innovation in SMEs

Central European Management Journal, 2022
Purpose: This study explores the knowledge development of network-based market orientation (MO) for the internationalization of disruptive innovation (DI) by small and medium-sized enterprises (SMEs).
Hyder Akmal S., Sundström Agneta, Chowdhury Ehsanul H.   +2 more
doaj   +1 more source

Influence of streptococcal arginine deiminase on the leukocyte infiltration in murine air pouch model

Медицинская иммунология, 2021
Numerous pathogens express arginine deiminase, an enzyme that catalyzes the hydrolysis of L-arginine in a chain of biochemical reactions aimed at the synthesis of ATP in bacterial cells. L-arginine is a semi-essential, proteinogenic amino acid that plays
E. A. Starikova, I. V. Kudryavtsev, L. A. Burova, A. M. Lebedeva, J. T. Mammedova, I. S. Freidlin   +5 more
doaj   +1 more source

S. pyogenes M49-16 arginine deiminase inhibits proliferative activity of human peripheral blood lymphocytes

Инфекция и иммунитет, 2021
Arginine deiminase is one of three enzymes constituting the arginine deiminase system in bacteria. It was demonstrated that arginine deiminase exerts anti-proliferative effects on some primary and immortalized mouse and human cells.
E. A. Starickova, T. A. Leveshko, D. V. Churakina, I. V. Kudryavtsev, L. A. Burova, I. S. Freidlin   +5 more
doaj   +1 more source

Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro

Microorganisms, 2023
Pathogenic microbes use arginine-metabolizing enzymes as an immune evasion strategy. In this study, the impact of streptococcal arginine deiminase (ADI) on the human peripheral blood T lymphocytes function in vitro was studied.
Eleonora A. Starikova, Jennet T. Mammedova, Arina Ozhiganova, Tatiana A. Leveshko, Aleksandra M. Lebedeva, Alexey V. Sokolov, Dmitry V. Isakov, Alena B. Karaseva, Larissa A. Burova, Igor V. Kudryavtsev   +9 more
doaj   +1 more source

A "ligand-targeting" peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis.

PLoS ONE, 2021
As a new alternative to antibody-drug conjugates, we generated "ligand-targeting" peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery.
Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii   +5 more
doaj   +1 more source