Yeast Ortholog of Peptidase Family M49: the Role of Invariant Glu461 and Tyr327 [PDF]
Croatica Chemica Acta, 2012 Metallopeptidase family M49 is characterized by five conserved sequence regions and the unique motif HEXXGH with two histidines - ligands of the active-site zinc ion. The crystal structure of the yeast ortholog represents a prototype for the whole family.
Jajčanin-Jozić, Nina +2 more
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Conservation of the conformational dynamics and ligand binding within M49 enzyme family
RSC Advances, 2018 The hydrogen deuterium exchange (HDX) mass spectrometry combined with molecular dynamics (MD) simulations was employed to investigate conformational dynamics and ligand binding within the M49 family (dipeptidyl peptidase III family).
Agić, Dejan +25 more
core +6 more sources
Diversidad genética de papas nativas (Solanum spp.) del distrito de Vilcashuamán, Ayacucho- Perú, mediante AFLP [PDF]
Revista Peruana de Biología, 2018 En este presente trabajo, la diversidad genética de 30 morfotipos de papas nativas de Vilcashuamán (Ayacucho) fue evaluada mediante la técnica de polimorfismo de longitud de fragmentos amplificados (AFLP). La extracción de ADN se realizó con el método de
Yessenia K. Remón Gamboa +1 more
doaj +2 more sources
What are the progenitors of the intragroup light stars around M49? [PDF]
, 2019 The interactions between galaxies in dynamically rich environments like clusters and groups of galaxies lead to the libration of stars that form the diffuse intra-cluster or intra-group light (IGL). The IGL is a good laboratory to study the properties of
Hartke, Johanna +1 more
core +3 more sources
The halo of M 49 and its environment as traced by planetary nebulae populations [PDF]
Proceedings of the International Astronomical Union, 2016 Context. The galaxy M49 (NGC 4472) is the brightest early-type galaxy in the Virgo Cluster. It is located in subcluster B and has an unusually blue, metal-poor outer halo.
Ken Freeman +19 more
core +3 more sources
La difficile gestione degli orsi “problematici”: il caso dell’esemplare M49
Rivista giuridica dell'ambiente : 2, 2022, 2022 This paper is aimed at studying the policies for the managment of “troubled” bears, which have been adopted by the Autonomous Province of Trento (PAT) over the last few years in the light of legal framework of general (State and supranational) and ...
GIUSEPPE GARZIA
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Identification of novel growth phase- and media-dependent small non-coding RNAs in
BMC Genomics, 2012 Background Small non-coding RNAs (sRNAs) have attracted attention as a new class of gene regulators in both eukaryotes and bacteria. Genome-wide screening methods have been successfully applied in Gram-negative bacteria to identify sRNA regulators.
Patenge Nadja +9 more
doaj +2 more sources
EFFECT OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES ON CYTOSKELETON STRUCTURE AND MIGRATION ACTIVITY OF HUMAN ENDOTHELIAL CELLS [PDF]
Медицинская иммунология, 2017 There is a growing body of data about the cytopathic effect of bacterial arginine deiminase on human endothelial cells, but the precise mechanisms of endothelial dysfunction caused by the activity of the enzyme remain poorly understood.
E. A. Starikova +5 more
doaj +2 more sources
Photometric Study of the Globular Cluster System of M49 [PDF]
, 2015 This thesis presents deep photometry of the globular cluster system of the massive elliptical galaxy, M49. Using the C and T1 Washington filters from the MOSAIC camera on the Cerro Tololo Inter-American Observatory 4m telescope, we studied the color ...
Mahmoud-Perez, Aisha
core +3 more sources
Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches. [PDF]
ChemMedChemThis paper by Kollár et al. reports a covalent fragment linking study against the SARS‐CoV‐2 main protease (3CLPro). Beginning with inactive fragment hits, the application of rational linker design enabled the generation of reversible covalent inhibitors exhibiting low micromolar potency. The study details some general limitations and best practices of
Kollár L +8 more
europepmc +2 more sources