Results 21 to 30 of about 2,790 (218)

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics. [PDF]

open access: yesPharmacol Res Perspect
ABSTRACT The invention of a therapeutic begins by characterizing features that differentiate healthy versus diseased states; this often presents as changes in the concentration of an analyte. Examples include elevated blood glucose in diabetes, high cholesterol in heart disease, and protein aggregation in neurodegeneration.
Kohnz RA   +10 more
europepmc   +2 more sources

Targeting Cryptochromes in Chronic Diseases. [PDF]

open access: yesCell Biol Int
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Toda T, Hirota T.
europepmc   +2 more sources

Analysis and Simulation of Glioblastoma Cell Lines-Derived Extracellular Vesicles Metabolome

open access: yesMetabolites, 2020
Glioblastoma (GBM) is one of the most aggressive cancers of the central nervous system. Despite current advances in non-invasive imaging and the advent of novel therapeutic modalities, patient survival remains very low.
Miroslava Čuperlović-Culf   +5 more
doaj   +1 more source

Analysis of the Relationship Between the Development of Performance Criteria and Job Performance of Employees with Respect to the Mediating Role of Employee Participation

open access: yesStudia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2023
The main purpose of this study is to investigate and analyze Positive and significant impact of defining employee performance criteria with the objectives: evaluation, empowerment and career development on the job performance of Keshavarzi Bank of Iran ...
Fallahnejad Ali   +2 more
doaj   +1 more source

Turquoise Management Model in Knowledge-Based Organisations

open access: yesStudia Ekonomiczne i Regionalne, 2023
The commercial success of an organisation is based on its unique characteristics which make it stand out from its competitors. It can be the result of as many factors as there are many types of organisations and the goals they pursue.
Fałda Beata, Małkowska Maria Alicja
doaj   +1 more source

Promoting hotel employees’ work engagement and its service outcomes: The critical role of intrinsic motivation

open access: yesInternational Journal of Management and Economics, 2023
The purpose of this article is to investigate the relationship between intrinsic job-related motivators and hotel employees’ work engagement and to examine how it may correlate with important employees’ outcomes, such as the prescribed-role and extra ...
Grobelna Aleksandra   +1 more
doaj   +1 more source

Mediation effect of psychological contract between personality dimensions and turnover intention [PDF]

open access: yesJournal of Economics Finance and Administrative Science, 2020
Purpose – This study aims to test the mediating role of psychological contract (PC) in a relationship between personality dimensions and turnover intention. Design/methodology/approach – The current study is analytical in nature. The data for the purpose
Maryam Saeed
doaj   +1 more source

The Effects of Electronic Surveillance on Job Tension, Task Performance and Organizational Trust

open access: yesBusiness Systems Research, 2021
Background: In contemporary work models, employees use the Internet and electronic devices more than ever. This phenomenon has also changed the way of monitoring employees and generated a new form called ‘electronic surveillance’.
Doğru Çağlar
doaj   +1 more source

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