Results 161 to 170 of about 63,662 (384)
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Nature, 2019 DNA and histone modifications have notable effects on gene expression1. Being the most prevalent internal modification in mRNA, the N6-methyladenosine (m6A) mRNA modification is as an important post-transcriptional mechanism of gene regulation2–4 and has
Huilin Huang +41 more
semanticscholar +1 more source
The m6A methyltransferase WTAP plays a key role in the development of diffuse large B-cell lymphoma via regulating the m6A modification of catenin beta 1 [PDF]
, 2022 Shuangshuang Guo +7 more
openalex +1 more source
This thesis investigates new therapeutic strategies for heart disease by exploring early cardiac development. Cardiomyocytes, the heart’s contractile cells, lose their ability to repair themselves after birth, leading to permanent damage after injury.
openaire +2 more sources
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Comprehensive Analysis of Crucial m6A-Related Differentially Expressed Genes in Psoriasis
Frontiers in Bioscience-LandmarkBackground: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors.
Lu Gan, Xuejingzi Wu, Jiquan Song
doaj +1 more source
International Journal of COPD, 2023 Tingting Hu,1,* Nannan Pang,2,* Zheng Li,1 Dan Xu,1 Jing Jing,1 Fengsen Li,1 Jianbing Ding,3 Jing Wang,1 Min Jiang1 1Xinjiang Laboratory of Respiratory Disease Research, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical ...
Hu T +8 more
doaj
An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu +12 more
wiley +1 more source
Insights into organelle forming RNAs: Diversity, functions and future perspectives
Animal Models and Experimental Medicine, EarlyView.RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley +1 more source
m6A modification in cancer regulation: molecular circuits and regulatory networks
Visualized Cancer MedicineThe N6-methyladenosine (m6A) modification is a significant research direction in the field of epitranscriptomics, and its multifaceted functions in tumor regulation have garnered increasing attention.
Li Yiming +7 more
doaj +1 more source