Results 151 to 160 of about 36,922 (295)

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Circular RNAs Biogenesis, Regulatory Mechanisms, and Their Future Applications in Laboratory Medicine [PDF]

Journal of Basic Research in Medical Sciences
Introduction: Circular RNAs (circRNAs)- once considered splicing artifacts- are covalently closed RNA molecules generated through back-splicing, lacking 5′ caps and 3′ poly(A) tails, which confers them with remarkable stability.
Maryam Kheiry, Ali Noori-Zadeh
doaj  

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing

Abstract The nuclear METTL3-METTL14 transfers a methyl group from SAM to convert the N6 of adenosine (A) in RNA to m6A and in ssDNA to 6mA. m6A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in a context-dependent manner. The cytoplasmic METTL3 can act as a m6A reader.
Shan Qi, Abhay Kumar, Shuang Chen, Shuo Zhou, Manish Parihar, Carmen Villalobos, Navom Gupta, Siu-Hong Chan, Manjeet K. Rao, Stanton F. McHardy, Shozeb Haider, Yogesh K. Gupta   +11 more
openaire   +2 more sources

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

CRISPR-C2c2法を用いたRNAエピジェネティクス編集法の開発 [PDF]

, 2020
本研究では特異的なmRNAのm6A修飾を編集する技術を開発し、m6Aの機能解析とm6A修飾異常疾患に対するRNA編集法の開発を目的とする。RNAメチル化編集プラットフォームの開発として、約80％程度の脱メチル化編集に成功している。また新たな評価系としてメチル化RNA感受性RNaseであるMazFを用いた高感度メチル化評価法を開発した。従来の抗体を用いたIP法と比較してより精度の高い編集効率を算出することが可能となった。これらのRNA編集システムおよび ...
盛, 真友
core  

RBMX Transcriptionally Repressed by EZH2‐Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang, Yan Teng, Fang‐Lan Yao, Shu‐Qi Wei, Yan Li   +4 more
wiley   +1 more source

MDM2–GPX4–ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage

Neural Regeneration Research
Ferroptosis plays a key role in nerve injury in intracerebral hemorrhage and is associated with the upregulation of murine double minute 2. Investigating the mechanism underlying murine double minute 2-related ferroptosis could help identify new ...
Yunhu Yu, Tao Liu, Yunpeng Cai, Yuanmei Song, Hang Zhou, Fang Cao, Rongcai Jiang   +6 more
doaj   +1 more source

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

, 2019
Aims Deregulation of epigenetic processes and aberrant gene expression are important mechanisms in heart failure. Here we studied the potential relevance of m6A RNA methylation in heart failure development.
Toischer, Karl, Tea Berulava, Cleve, Nicole, Jain, Gaurav, Fischer, Andre, Susanne Burkhardt, Tonatiuh Pena, Sacherer, Michael, Eric Buchholz, Vakhtang Elerdashvili, Gerd Hasenfuss, Vincenzo Capece, Buchholz, Eric, Bohnsack, Markus T., Nicole Cleve, Lewinski, Dirk, Gaurav Jain, Burkhardt, Susanne, Islam, Md Rezaul, Andre Renner, Andre Fischer, Lbik, Dawid, Mohamed, Belal A., Dirk von Lewinski, Markus T. Bohnsack, Elerdashvili, Vakhtang, Renner, Andre, Michael Sacherer, Berulava, Tea, Bohnsack, Katherine E., Katherine E. Bohnsack, Pena, Tonatiuh, Dawid Lbik, Belal A. Mohamed, Md Rezaul Islam, Hasenfuss, Gerd, Karl Toischer, Capece, Vincenzo   +37 more
core   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source