Results 131 to 140 of about 36,922 (295)
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
This thesis investigates new therapeutic strategies for heart disease by exploring early cardiac development. Cardiomyocytes, the heart’s contractile cells, lose their ability to repair themselves after birth, leading to permanent damage after injury.
openaire +2 more sources
European Journal of Organic Chemistry, EarlyView.DNA architectures with aminonaphthalimides and cyanovinylenes as base surrogates form interstrand and intrastrand dimers showed that can be used as nucleic acid‐sensitive probes by their fluorescence turn‐on and red‐shift as readouts. The fluorescence turn‐on was tested by probing N6‐methyl‐2’‐deoxyadenosine (m6A) in DNA.
Jan Kunzmann +2 more
wiley +1 more source
Comprehensive Analysis of Crucial m6A-Related Differentially Expressed Genes in Psoriasis
Frontiers in Bioscience-LandmarkBackground: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors.
Lu Gan, Xuejingzi Wu, Jiquan Song
doaj +1 more source
International Journal of COPD, 2023 Tingting Hu,1,* Nannan Pang,2,* Zheng Li,1 Dan Xu,1 Jing Jing,1 Fengsen Li,1 Jianbing Ding,3 Jing Wang,1 Min Jiang1 1Xinjiang Laboratory of Respiratory Disease Research, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical ...
Hu T +8 more
doaj
Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes
iMeta, EarlyView.Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang +27 more
wiley +1 more source
An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
m6A modification in cancer regulation: molecular circuits and regulatory networks
Visualized Cancer MedicineThe N6-methyladenosine (m6A) modification is a significant research direction in the field of epitranscriptomics, and its multifaceted functions in tumor regulation have garnered increasing attention.
Li Yiming +7 more
doaj +1 more source