Results 111 to 120 of about 36,922 (295)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

, 2020
RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear RNA.
Jessica Leismann, Graille, Marc, Jean‐Yves Roignant, Ludivine Wacheul, Marc Graille, Mier, Pablo, Spagnuolo, Mariangela, Niehrs, Christof, Mariangela Spagnuolo, Roignant, Jean‐yves, Mihika Pradhan, Pablo Mier, Denis LJ Lafontaine, Roignant, Jean-Yves, Christof Niehrs, Miguel A Andrade‐Navarro, Michael Musheev, Leismann, Jessica, Vu, Minh Anh, Lafontaine, Denis Lj, Pradhan, Mihika, Wacheul, Ludivine, Andrade‐navarro, Miguel, Minh Anh Vu, Lafontaine, Denis, Andrade-Navarro, Miguel Angel, Musheev, Michael   +26 more
core   +1 more source

Additional file 2 of Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas

, 2022
Additional file 2: Fig. S2. Construction procedures of cluster model with non-m6A-related lncRNAs. A Left, consensus matrices of the TCGA samples, showing consensus matrices with k =2-5. Right, the cluster-consensus value for k = 2-9.
Zenxin Cao (14032260), Feihu Zhao (8692689), Bin Huang (331329), Wenbo Zhao (494837), Zhiyi Xue (12045578), Wenyu Liu (441933), Xingang Li (14032263), Yibo Wu (788885), Zhimin Zhao (335570), Mingzhi Han (4285534)   +9 more
core   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Additional file 17 of Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas

, 2022
Additional file 17: Table S6.
Zenxin Cao (14032260), Feihu Zhao (8692689), Bin Huang (331329), Wenbo Zhao (494837), Zhiyi Xue (12045578), Wenyu Liu (441933), Xingang Li (14032263), Yibo Wu (788885), Zhimin Zhao (335570), Mingzhi Han (4285534)   +9 more
core   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Regulation of FTO on PDCD5 mRNA stability to mediate neuron apoptosis in rats with hypoxic-ischemic brain damage

Translational Neuroscience
This study explored the mechanism of FTO in regulating neuron apoptosis in hypoxic-ischemic brain damage (HIBD) models via PDCD5.
Yin Taiyong, Zou Minshu, Liu Dali, Shao Cui, Li Shuangshuang, Yuan Hui, Xu Hongtao   +6 more
doaj   +1 more source

METTL3-mediated miR-4534 maturation promotes IVDD progression by targeting the Sirt6-mediated Nrf2/HO-1 pathway

Archives of Medical Science
Introduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
doaj   +1 more source

fiberseq/train-m6A-calling: v0.0.1

ML methods for m6A ...
StephanieBohaczuk, alantmin, Mitchell Robert Vollger, MorganHamm, Anupama Jha   +4 more
core   +1 more source