Results 101 to 110 of about 46,200 (286)

Nodal inequalities on surfaces

, 2006
Given a Laplace eigenfunction on a surface, we study the distribution of its extrema on the nodal domains. It is classically known that the absolute value of the eigenfunction is asymptotically bounded by the 4-th root of the eigenvalue.
Chavel, Kronrod, LEONID POLTEROVICH, MIKHAIL SODIN, Sogge   +4 more
core   +3 more sources

Towards the higher point holographic momentum space amplitudes [PDF]

, 2019
In this paper, we calculate higher point tree level vector amplitudes propagating in AdS$_4$. We use bulk perturbation theory to compute tree level Witten diagrams.
Albayrak, Soner, Kharel, Savan
core   +4 more sources

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

Erratum to: Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia [PDF]

, 2017
Methylation of N6 adenosine (m6A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing.
Amy D. Marshall, Chau-To Kwok, John E. J. Rasko, Justin J. L. Wong   +3 more
core   +2 more sources

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells [PDF]

, 2017
Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL contacts genome-wide in single human cells.
Amendola, Mario, Bienko, Magda, Dekker, Job, Dey, Siddharth S., de Graaf, Carolyn A., de Vries, Sandra S., Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Jalink, Kees, Kind, Jop, Lajoie, Bryan, Mirny, Leonid A, Nahidiazar, Leila, Pagie, Ludo, van Oudenaarden, Alexander, van Steensel, Bas, Zhan, Ye   +16 more
core   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation

Open Medicine
This study aims to investigate the potential of electroacupuncture to mitigate myocardial ischemia–reperfusion injury (MIRI) by influencing N6-methyladenosine (m6A) methylation through modulation of the fat mass and obesity-associated protein (FTO).
Zou Ying-Hua, Zhou En, Xie Chen-Long, Sun Long, Zhang Yu-Jiao, Wang Chun-Chun, Li Xing, Guo Jun   +7 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source