Results 101 to 110 of about 40,511 (310)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Additional file 13 of Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas

, 2022
Additional file 13: Table S2.
Zenxin Cao (14032260), Feihu Zhao (8692689), Bin Huang (331329), Wenbo Zhao (494837), Zhiyi Xue (12045578), Wenyu Liu (441933), Xingang Li (14032263), Yibo Wu (788885), Zhimin Zhao (335570), Mingzhi Han (4285534)   +9 more
core   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

The Role and Molecular Mechanism of N⁶-methyladenosine Modification in Spermatogenesis

Shengwu huaxue yu shengwu wuli jinzhan
Spermatogenesis is a highly ordered and spatiotemporally regulated developmental process in the male reproductive system, during which spermatogonial stem cells (SSCs), supported by the seminiferous tubule microenvironment, sequentially undergo mitosis ...
MENG Shi-Qi, LU Wen-Ting, CHENG Xu, YANG Fan, NIU Chang-Min, ZHEGN Ying   +5 more
doaj   +1 more source

fiberseq/train-m6A-calling: v0.0.1

ML methods for m6A ...
StephanieBohaczuk, alantmin, Mitchell Robert Vollger, MorganHamm, Anupama Jha   +4 more
core   +1 more source

The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

, 2020
RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear RNA.
Jessica Leismann, Graille, Marc, Jean‐Yves Roignant, Ludivine Wacheul, Marc Graille, Mier, Pablo, Spagnuolo, Mariangela, Niehrs, Christof, Mariangela Spagnuolo, Roignant, Jean‐yves, Mihika Pradhan, Pablo Mier, Denis LJ Lafontaine, Roignant, Jean-Yves, Christof Niehrs, Miguel A Andrade‐Navarro, Michael Musheev, Leismann, Jessica, Vu, Minh Anh, Lafontaine, Denis Lj, Pradhan, Mihika, Wacheul, Ludivine, Andrade‐navarro, Miguel, Minh Anh Vu, Lafontaine, Denis, Andrade-Navarro, Miguel Angel, Musheev, Michael   +26 more
core   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Comprehensive Analysis of Crucial m6A-Related Differentially Expressed Genes in Psoriasis

Frontiers in Bioscience-Landmark
Background: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors.
Lu Gan, Xuejingzi Wu, Jiquan Song
doaj   +1 more source

The Activation of M1 Macrophages is Associated with the JNK-m6A-p38 Axis in Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2023
Tingting Hu,1,* Nannan Pang,2,* Zheng Li,1 Dan Xu,1 Jing Jing,1 Fengsen Li,1 Jianbing Ding,3 Jing Wang,1 Min Jiang1 1Xinjiang Laboratory of Respiratory Disease Research, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical ...
Hu T, Pang N, Li Z, Xu D, Jing J, Li F, Ding J, Wang J, Jiang M   +8 more
doaj  

m6A-TSHub: Unveiling the Context-specific m6A Methylation and m6A-affecting Mutations in 23 Human Tissues

, 2023
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs (lncRNAs), N6-methyladenosine (m6A) RNA methylation has been shown to participate in essential biological processes.
Yuxin Zhang, Pedro de Magalhães, J, João Pedro de Magalhães, Rigden, DJ, Zhang, Y, Kunqi Chen, Daniel J. Rigden, Huang, D, Chen, K, Su, J, Meng, J, Song, B, Jionglong Su, Bowen Song, Zhen Wei, Daiyun Huang, Jia Meng, Wei, Z   +17 more
core   +1 more source