Results 81 to 90 of about 46,200 (286)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling

Frontiers in Bioscience-Landmark
Background: The importance of N6-methyladenosine (m6A) modification in tumorigenesis and progression have been highlighted. This study aimed to investigate the modification of insulin receptor substrate 1 (IRS1) by m6A and its role in oral squamous cell ...
Yanbo Xiao, Xuan Zhu, Qun Li, Zongkang Wang, Qiaojuan Zuo, Xun Liu, Jin Tan   +6 more
doaj   +1 more source

The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]

, 2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan, Anderson, James T., Entian, Karl-dieter, Hauenschild, Ralf, Helm, Mark, Hildebrandt, Andreas, Jaschke, Andres, Lafontaine, Denis L.J., Motorin, Yuri, Schmid, Katharina, Sharma, Sunny, Thuring, Kathrin, Tserovski, Lyudmil, Wacheul, Ludvine, Winz, Marie-Luise   +14 more
core   +1 more source

Altered expression of neuroplasticity-related genes in the brain of depressed suicides [PDF]

, 2015
Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals.
Alvarez Juliá, Anabel, Frasch, Alberto Carlos C., Fuchsova, Beata, Pandey, G. N., Rizavi, H. S.   +4 more
core   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Casimir Energies for 6D Supergravities Compactified on T_2/Z_N with Wilson Lines

, 2005
We compute (as functions of the shape and Wilson-line moduli) the one-loop Casimir energy induced by higher-dimensional supergravities compactified from 6D to 4D on 2-tori, and on some of their Z_N orbifolds.
, C.A. Scrucca, C.P. Burgess, C.P. Burgess, Clifford P Burgess, D. Ghilencea, Douglas Hoover, Dumitru M Ghilencea, E. Elizalde, E. Elizalde, E. Elizalde, E. Ponton, Fernando Quevedo, For reviews of the SLED proposal see C.P. Burgess, G. Azuelos, I. Antoniadis, I. Navarro, I. Navarro, I. Navarro, I. Navarro, I.S. Gradshteyn, J. Garriga, K. Kainulainen, L. De Nardo, N.A. Bahcall, P.H. Beauchemin, S. Groot Nibbelink, S. Matsuda, S. Randjbar-Daemi, S. Weinberg, S.M. Carroll, Supernova Cosmology Project collaboration, Supernova Search Team collaboration, V.P. Nair, Y. Aghababaie .   +34 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

m6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia

Epigenetics, 2023
Patients with acute myeloid leukaemia (AML) have poor prognoses and low overall survival (OS) rates owing to its heterogeneity and the complexity of its tumour microenvironment (TME).
Xinai Liao, Ling Chen, Jingru Liu, Haoran Hu, Diyu Hou, Ruolan You, Xiaoting Wang, Huifang Huang   +7 more
doaj   +1 more source

Bayesian nonparametric models for spatially indexed data of mixed type [PDF]

, 2014
We develop Bayesian nonparametric models for spatially indexed data of mixed type. Our work is motivated by challenges that occur in environmental epidemiology, where the usual presence of several confounding variables that exhibit complex interactions ...
Best, Nicky, Papageorgiou, Georgios, Richardson, Sylvia   +2 more
core   +2 more sources

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source