Results 71 to 80 of about 46,200 (286)

Biomarkers Associated with Immune Checkpoint, N6-Methyladenosine, and Ferroptosis in Patients with Restenosis

Journal of Inflammation Research, 2023
Xiao Tong, Xinyi Zhao, Xuan Dang, Yan Kou, Junjie Kou Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, People’s Republic of ...
Tong X, Zhao X, Dang X, Kou Y, Kou J
doaj  

Progress and application of epitranscriptomic m6A modification in gastric cancer

RNA Biology, 2022
The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
doaj   +1 more source

Non-Gaussianity from Lifshitz Scalar

, 2010
A Lifshitz scalar with the dynamical critical exponent z = 3 obtains scale-invariant, super-horizon field fluctuations without the need of an inflationary era.
, B. Chen, C. Charmousis, C. Cheung, C. Cheung, C.T. Byrnes, C.T. Byrnes, D. Babich, D. Langlois, D. Langlois, D. Seery, D. Seery, D. Seery, D. Seery, E. Komatsu ., F. Arroja, G. Calcagni, H.R.S. Cogollo, J. Khoury, J.M. Maldacena, K. Izumi, Keisuke Izumi, L. Kofman, L. Senatore, M. Kawasaki, N. Arkani-Hamed, N. Bartolo, P. Creminelli, Q.-G. Huang, Q.-G. Huang, Q.-G. Huang, R. Holman, S. Mizuno, S. Mukohyama, S. Mukohyama, S. Mukohyama, S. Renaux-Petel, Shinji Mukohyama, T. Harada, T. Kobayashi, T. Suyama, Takeshi Kobayashi, X. Chen, X. Chen, X. Chen, X. Chen, X. Gao, X. Gao, X. Gao, X. Gao   +49 more
core   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson ...
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen   +7 more
doaj   +1 more source

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source

Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Recent advances in dynamic m6A RNA modification [PDF]

Open Biology, 2016
The identification of m6A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m6A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years.
Guangchao Cao, Hua-Bing Li, Zhinan Yin, Richard A. Flavell   +3 more
doaj   +1 more source

Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]

, 2015
Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan, Bodi, Zsuzsanna, Bottley, Andrew, Fray, Rupert G., May, Sean, May, Sean T.   +5 more
core   +3 more sources