Results 91 to 100 of about 46,200 (286)

Comprehensive Analysis of Crucial m6A-Related Differentially Expressed Genes in Psoriasis

Frontiers in Bioscience-Landmark
Background: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors.
Lu Gan, Xuejingzi Wu, Jiquan Song
doaj   +1 more source

The Activation of M1 Macrophages is Associated with the JNK-m6A-p38 Axis in Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2023
Tingting Hu,1,* Nannan Pang,2,* Zheng Li,1 Dan Xu,1 Jing Jing,1 Fengsen Li,1 Jianbing Ding,3 Jing Wang,1 Min Jiang1 1Xinjiang Laboratory of Respiratory Disease Research, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical ...
Hu T, Pang N, Li Z, Xu D, Jing J, Li F, Ding J, Wang J, Jiang M   +8 more
doaj  

m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

Epigenetics, 2022
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related protein (FTO) promote the growth, migration and invasion of PC.
Wei Wang, Ying He, Lu-Lu Zhai, Long-Jiang Chen, Li-Chao Yao, Lun Wu, Zhi-Gang Tang, Jin-Zhuo Ning   +7 more
doaj   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

Epimetronomics: m6A Marks the Tempo of Corticogenesis [PDF]

Neuron, 2017
Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation.
Nathan C, Boles, Sally, Temple
openaire   +2 more sources

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Probing the structure of the cold dark matter halo with ancient mica

, 1997
Mica can store (for >1 Gy) etchable tracks caused by atoms recoiling from WIMPs. Ancient mica is a directional detector despite the complex motions it makes with respect to the WIMP "wind".
Andrew J. Westphal, C. Lacey, C. Lacey, D. P. Snowden-Ifft, D. P. Snowden-Ifft, D. P. Snowden-Ifft, Daniel P. Snowden-Ifft, E. R. Capriotti, Edward A. Baltz, G. Jungman, J. Binney, J. F. Navarro, J. F. Navarro, J. F. Navarro, K. V. Johnston, L. Hernquist, R. Bernabei, V. Trimble, W. H. Press   +18 more
core   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

m6A modification in cancer regulation: molecular circuits and regulatory networks

Visualized Cancer Medicine
The N6-methyladenosine (m6A) modification is a significant research direction in the field of epitranscriptomics, and its multifaceted functions in tumor regulation have garnered increasing attention.
Li Yiming, Zhu Kunrui, Feng Yanqi, Yao Shuxi, Han Yuelin, Xiao Xiangtian, Han Zhuoyan, Xia Shu   +7 more
doaj   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source