Results 61 to 70 of about 46,200 (286)

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker, B Moindrot, C Church, C Schütt, C Trapnell, CF Hongay, D Dominissini, D Kim, D Sturgill, D Yan, DP Patil, E Zaharieva, Eugenio Sanchez-Moran, GZ Luo, Helen K. Salz, Irmgard U. Haussmann, IU Haussmann, IU Haussmann, IU Haussmann, J Liu, J Zhou, JA Bokar, JE Harper, JT Robinson, K Horiuchi, KD Meyer, KD Meyer, KJ Livak, LO Penalva, M Niessen, M Soller, M Soller, M Soller, Matthias Soller, Nathan Archer, Nigel P. Mongan, RP Perry, Rupert G. Fray, S Geula, S Ke, S Luo, S Schwartz, S Zhong, SR Starck, W Xiao, X Wang, Z Bodi, Z Bodi, Zsuzsanna Bodi   +48 more
core   +5 more sources

m6A methyltransferase METTL3 promotes the progression of prostate cancer via m6A-modified LEF1.

European review for medical and pharmacological sciences, 2020
This study aims to uncover the regulatory effects of METTL3 on promoting the progression of prostate cancer (PCa) through N6-Methyladenosine (m6A) methylation on LEF1 mRNA.The relative levels of METTL3 and LEF1 in 48 paired PCa tissues and adjacent ones were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).
Ma, X.-X., Cao, Z.-G., Zhao, S.-L.
openaire   +2 more sources

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

FTO: linking m6A demethylation to adipogenesis [PDF]

Cell Research, 2014
Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood.
Moshe Shay, Ben-Haim, Sharon, Moshitch-Moshkovitz, Gideon, Rechavi   +2 more
openaire   +2 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer

Cancer Management and Research, 2020
Li-chao Xu,1,2,* Jing-xin Pan,3,* Hong-da Pan2 1Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University ...
Xu L, Pan J, Pan H
doaj  

Star and protoplanetary disk properties in Orion's suburbs

, 2009
(Note: this is a shortened version of the original "structured" A&A format abstract.) We performed a large optical spectroscopic and photometric survey of the Lynds~1630N and 1641 clouds.
A. Carmona, A. Sicilia-Aguilar, Acke, Acke, Acke, Adams, Akeson, Akeson, Alcalá, Alexander, Allen, Alonso-Albi, Alves, Anderson, Andrews, Anthony-Twarog, Artymowicz, Bally, Baraffe, Barrado y Navascués, Barrado y Navascués, Bertout, Bouwman, Briceño, Briceño, Béjar, Calvet, Calvet, Calvet, Cardelli, Carpenter, Cieza, Cieza, Cieza, Clarke, Comerón, D'Alessio, D'Antona, Dahm, Dahm, Dahm, Dahm, Diolaiti, Dotter, Dullemond, Eisner, Eisner, Evans, Evans, Evans, Fazio, Fedele, Fedele, Finkbeiner, Flaherty, Furlan, Garcia Lopez, Gatti, Genzel, Gullbring, Gustafsson, Gutermuth, Gutermuth, Gâlfalk, Haisch, Hamann, Hartigan, Hartigan, Hartigan, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Henning, Herbig, Herbig, Herczeg, Hernández, Hernández, Hernández, Hernández, Hillenbrand, Hillenbrand, Hillenbrand, Hirota, Huélamo, Isella, Kenyon, Kenyon, Kramer, Kraus, Kurucz, Kurucz, Kwan, Lada, Lada, Leinert, Lombardi, Luhman, Luhman, Luhman, M. Fang, Maddalena, Mamajek, Meeus, Megeath, Miesch, Mohanty, Monnier, Monnier, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Najita, Natta, Natta, Osterloh, Quillen, R. van Boekel, Reipurth, Rice, Rieke, Román-Zúñiga, Rucinski, Sacco, Setiawan, Shu, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Siess, Siess, Skrutskie, Spezzi, Strom, Strom, Th. Henning, Valdes, van der Plas, Vinkovic, Vinkovic, W. Wang, White, Wilson, Winston, Young   +152 more
core   +2 more sources

Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis [PDF]

, 2011
The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Cheng, Zhe, Gu, Fengshou, Hu, Niaoqing, Qin, Guojun   +3 more
core   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source