Results 41 to 50 of about 30,145 (267)

Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing

Epigenetics, 2021
Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC).
Zhen Zhang, Quan Wang, Mengmeng Zhang, Wei Zhang, Long Zhao, Changjiang Yang, Bo Wang, Kewei Jiang, Yingjiang Ye, Zhanlong Shen, Shan Wang   +10 more
doaj   +1 more source

m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

Exploration of Medicine, 2023
m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs.
Hiromichi Sato, Tomoaki Hara, Chihiro Otsuka, Yasuko Arao, Yoshiko Tsuji, Yumiko Hamano, Mirei Ogita, Eric di Luccio, Takaaki Hirotsu, Andrea Vecchione, Hideshi Ishii   +10 more
doaj   +1 more source

METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

Epigenetics, 2023
Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou, Yukun Cao, Yuan Yang, Shouman Wang, Feiyu Chen   +4 more
doaj   +1 more source

The Role of M6a in Angiogenesis and Vascular Diseases

iScience, 2023
Angiogenesis, whether physiological or pathological, plays a pivotal role in various physiological and disease conditions. This intricate process relies on a complex and meticulously orchestrated signal transduction network that connects endothelial cells, their associated parietal cells (VSMCs and pericytes), and various other cell types, including ...
Chen, Ke, Li, Wen-Dong, Li, Xiao-Qiang
openaire   +2 more sources

Impaired Prosodic Processing but Not Hearing Function Is Associated with an Age-Related Reduction in AI Speech Recognition

Audiology Research
Background/Objectives: Voice artificial intelligence (AI) technology is becoming increasingly common. Recent work indicates that middle-aged to older adults are less able to identify modern AI speech compared to younger adults, but the underlying causes ...
Björn Herrmann, Mo Eric Cui
doaj   +1 more source

RNA modification m6Am: the role in cardiac biology

Epigenetics, 2023
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due to their vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology.
Daniel Benak, Frantisek Kolar, Lu Zhang, Yvan Devaux, Marketa Hlavackova   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Development and Validation of a Prognostic Index Based on Genes Participating in Autophagy in Patients With Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundLung adenocarcinoma (LUAD) is a deadly respiratory system malignancy with poor prognosis. Autophagy is essential for the beginning, development, and therapy resistance of cancer.
Zi-Xuan Wu, Xuyan Huang, Min-Jie Cai, Pei-Dong Huang, Zunhui Guan   +4 more
doaj   +1 more source