Results 121 to 130 of about 36,922 (295)

m6A-TSHub: Unveiling the Context-specific m6A Methylation and m6A-affecting Mutations in 23 Human Tissues

, 2023
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs (lncRNAs), N6-methyladenosine (m6A) RNA methylation has been shown to participate in essential biological processes.
Yuxin Zhang, Pedro de Magalhães, J, João Pedro de Magalhães, Rigden, DJ, Zhang, Y, Kunqi Chen, Daniel J. Rigden, Huang, D, Chen, K, Su, J, Meng, J, Song, B, Jionglong Su, Bowen Song, Zhen Wei, Daiyun Huang, Jia Meng, Wei, Z   +17 more
core   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Biomarkers Associated with Immune Checkpoint, N6-Methyladenosine, and Ferroptosis in Patients with Restenosis

Journal of Inflammation Research, 2023
Xiao Tong, Xinyi Zhao, Xuan Dang, Yan Kou, Junjie Kou Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, People’s Republic of ...
Tong X, Zhao X, Dang X, Kou Y, Kou J
doaj  

Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat

Angewandte Chemie, EarlyView.
Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate

Angewandte Chemie International Edition, EarlyView.
Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer

Cancer Management and Research, 2020
Tong Liu,1 Sheng Yang,1 Yan-ping Cheng,1 Xiao-ling Kong,1 Dan-dan Du,1 Xian Wang,1 Yun-fei Bai,2 Li-hong Yin,1 Yue-pu Pu,1 Ge-yu Liang1 1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast ...
Liu T, Yang S, Cheng YP, Kong XL, Du DD, Wang X, Bai YF, Yin LH, Pu YP, Liang GY   +9 more
doaj  

N6-methyladenosine (m6A) regulates signaling pathways during early embryo development

, 2022
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. In recent years, a slew of interesting studies had confirmed its essential role as a post-transcriptional regulator of gene expression in a wide range of biological ...
Jin, Kangxuan
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts

, 2022
International audienceAbstract N6-Methyladenosine (m6A), one of the most abundant internal modification of eukaryotic mRNAs, participates in the post-transcriptional control of gene expression through recruitment of specific m6A readers. In Saccharomyces
Bertrand Séraphin, Zumsteg, Julie, Tommaso Villa, Julie Zumsteg, Matelot, Mélody, Jérémy Scutenaire, Villa, Tommaso, Damien Plassard, Séraphin, Bertrand, Scutenaire, Jérémy, Mélody Matelot, Plassard, Damien, Libri, Domenico, Domenico Libri   +13 more
core   +1 more source