Results 161 to 170 of about 40,511 (310)
The epigenetic landscape of plant defense: Unlocking nature's toolkit for new plant protection
New Plant Protection, EarlyView.This review examines how epigenetic mechanisms regulate plant immune gene activation, repression, and priming, then links these natural regulatory layers to emerging epigenetic editing, discussing their potential for precise, heritable crop protection and the challenges.
Xuexia Liu, Zhenhui Zhong
wiley +1 more source
Circular RNAs Biogenesis, Regulatory Mechanisms, and Their Future Applications in Laboratory Medicine [PDF]
Journal of Basic Research in Medical SciencesIntroduction: Circular RNAs (circRNAs)- once considered splicing artifacts- are covalently closed RNA molecules generated through back-splicing, lacking 5′ caps and 3′ poly(A) tails, which confers them with remarkable stability.
Maryam Kheiry, Ali Noori-Zadeh
doaj
Genomics and epigenomics of tissue repair: Implications for personalized medicine
Precision Medical Sciences, EarlyView.Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi +7 more
wiley +1 more source
Neuropsychiatric Disease and TreatmentMary Angelin,1 Padmavathi Gopinath,1 Vijaya Raghavan,1,2 Rangaswamy Thara,2 Faraz Ahmad,3 Arasamabattu Kannan Munirajan,1 Ravi Sudesh4 1Department of Genetics, University of Madras, Dr ALM PG Institute of Basic Medical Sciences, Taramani Campus, Chennai,
Angelin M +6 more
doaj
m6A-mediated translation regulation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 openaire +2 more sources
Phytotherapy Research, EarlyView.This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren +10 more
wiley +1 more source
m6A-Methylated NUTM2B-AS1 Promotes Hepatocellular Carcinoma Stemness Feature via Epigenetically Activating BMPR1A Transcription [PDF]
Wenchuan Li,1,2,* Min Zeng,3,* Yuanjia Ning,3,* Rongzhou Lu,3 Yunyu Wei,3 Zuoming Xu,2 Huamei Wei,1,4 Jian Pu1,2 1Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, Baise, People’s Republic of China; 2Department of ...
Li W +7 more
core
Phytotherapy Research, EarlyView.Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen +9 more
wiley +1 more source
Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity
Phytotherapy Research, EarlyView.Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun +5 more
wiley +1 more source
Small, EarlyView.Protein‐based multilayer microreactors combine single‐enzyme nanogels (SENs) and layer‐by‐layer (LbL) assembly to control catalase localization. Positioning the enzyme within the core or at different locations of the multilayer architecture reveals how spatial organization influences antioxidant and anti‐inflammatory activity.
Maria A. Motta +5 more
wiley +1 more source