Results 301 to 310 of about 58,783 (322)

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

Annals of the Rheumatic Diseases, 2021
Objective The aim of the study was to investigate the role and regulatory mechanisms of fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis (OA). Methods Synovial tissues from normal patients and patients with OA
Xiang Chen, W. Gong, Xiaoyan Shao, T. Shi, Lei Zhang, Jian Dong, Yong-zhao Shi, Siyu Shen, Jianghui Qin, Q. Jiang, Baosheng Guo   +10 more
semanticscholar   +1 more source

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

Science Translational Medicine, 2022
The role of N6-methyladenosine (m6A) modifications in renal diseases is largely unknown. Here, we characterized the role of N6-adenosine-methyltransferase-like 3 (METTL3), whose expression is elevated in renal tubules in different acute kidney injury ...
Jia-nan Wang, Fang Wang, Jing Ke, Zeng Li, Chuanjie Xu, Qin Yang, Xin Chen, Xiao-yan He, Yuan He, Xiao-guo Suo, Chao Li, Ju-tao Yu, Ling Jiang, W. Ni, Juan Jin, Ming-ming Liu, Wei Shao, Chen Yang, Qian Gong, Hai-yong Chen, Jun Li, Yong-gui Wu, Xiao-ming Meng   +22 more
semanticscholar   +1 more source

RNA m6A methylation regulators in sepsis

Molecular and Cellular Biochemistry, 2023
N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers" (
Lin, Zhu, Hairong, Zhang, Xiaoyu, Zhang, Lei, Xia   +3 more
openaire   +2 more sources

N6‐methyladenosine (m6A) Modification in Preeclampsia

Reproductive Sciences, 2023
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang, Ziyan Jiang, Nana Yang, Zhiping Ge, Qing Zuo, Shiyun Huang, Lizhou Sun   +6 more
openaire   +2 more sources

m6A mRNA modification regulates mammalian spermatogenesis

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N6-methyladenosine (m6A), an epitranscriptomic regulator of gene expression, can influence pre-mRNA splicing, mRNA export, turnover, and
Zhen, Lin, Ming-Han, Tong
openaire   +2 more sources

The roles and implications of RNA m6A modification in cancer

Nature Reviews Clinical Oncology, 2023
Xiaolan Deng, Y. Qing, D. Horne, Huilin Huang, Jianjun Chen   +4 more
semanticscholar   +1 more source

Viral RNA in an m6A disguise

Nature Microbiology, 2020
N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
openaire   +2 more sources

Mechanistic insights into m6A RNA enzymes

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past years owing to improvements of detection methods and the identification of important regulatory players. N6-methyladenosine (m6A) is the most abundant internal modification in messenger (mRNA) and long non-coding (lncRNA), and controls most steps of RNA ...
Tina Lence, Chiara Paolantoni, Lina Worpenberg, Jean-Yves Roignant   +3 more
openaire   +2 more sources

Regulation and functions of non-m6A mRNA modifications

Nature reviews. Molecular cell biology, 2023
Hanxiao Sun, Kai Li, Cong Liu, C. Yi
semanticscholar   +1 more source

m6A Modification and Implications for microRNAs

MicroRNA, 2017
RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes.Here, we review recent literature ...
Ayse Elif, Erson-Bensan, Oguzhan, Begik
openaire   +2 more sources