Results 141 to 150 of about 5,202 (155)
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Mac1+/Gr1+ cells contribute to transfusion-related acute lung injury
Transfusion and Apheresis Science, 2013Transfusion-related acute lung injury (TRALI) is a serious complication associated with blood transfusion and can cause transfusion associated fatalities. Both antibody dependent and non-dependent mechanisms are involved in TRALI, as proposed over the past years.
Xing-bin, Hu +4 more
exaly +3 more sources
Mapping of the DNA Binding Domain of the Copper-responsive Transcription Factor Mac1 from Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 1998 Mac1 from Saccharomyces cerevisiae activates transcription of genes, including CTR1 in copper-deficient cells. N-terminal fusions of Mac1 with the herpes simplex VP16 activation domain were used to show that residues 1-159 in Mac1 constitute the minimal DNA binding domain.
Matthew Posewitz +2 more
exaly +3 more sources
Biochemical Journal, 2020
The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results of other groups first and explain the differences from our results.
Yong-Sung Park +3 more
openaire +2 more sources
The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results of other groups first and explain the differences from our results.
Yong-Sung Park +3 more
openaire +2 more sources
Glia, 2007
AbstractMicroglia‐derived superoxide is critical for the inflammation‐induced selective loss of dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly defined. Using neuron‐glia and microglia‐enriched cultures from mice deficient in the MAC1 receptor (MAC1−/−), we demonstrate that lipopolysaccharide (LPS ...
Jau-Shyong Hong, Michelle Block
exaly +3 more sources
AbstractMicroglia‐derived superoxide is critical for the inflammation‐induced selective loss of dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly defined. Using neuron‐glia and microglia‐enriched cultures from mice deficient in the MAC1 receptor (MAC1−/−), we demonstrate that lipopolysaccharide (LPS ...
Jau-Shyong Hong, Michelle Block
exaly +3 more sources
Current Genetics, 2019
While it is known that ScRad9 DNA damage checkpoint protein is recruited to damaged DNA by recognizing specific histone modifications, here we report a different way of Rad9 recruitment on chromatin under non DNA damaging conditions. We found Rad9 to bind directly with the copper-modulated transcriptional activator Mac1, suppressing both its DNA ...
Kalliopi Gkouskou +2 more
exaly +3 more sources
While it is known that ScRad9 DNA damage checkpoint protein is recruited to damaged DNA by recognizing specific histone modifications, here we report a different way of Rad9 recruitment on chromatin under non DNA damaging conditions. We found Rad9 to bind directly with the copper-modulated transcriptional activator Mac1, suppressing both its DNA ...
Kalliopi Gkouskou +2 more
exaly +3 more sources
Biochemical and Biophysical Research Communications, 2020
The underlying mechanism of viral infection as a risk factor for Parkinson's disease (PD), the second most common neurodegenerative disease, remains unclear.We used Mac-1-/- and gp91phox-/- transgene animal models to investigate the mechanisms by which poly I:C, a mimic of virus double-stranded RNA, induces PD neurodegeneration.Poly I:C was ...
Weixing Xu +10 more
openaire +2 more sources
The underlying mechanism of viral infection as a risk factor for Parkinson's disease (PD), the second most common neurodegenerative disease, remains unclear.We used Mac-1-/- and gp91phox-/- transgene animal models to investigate the mechanisms by which poly I:C, a mimic of virus double-stranded RNA, induces PD neurodegeneration.Poly I:C was ...
Weixing Xu +10 more
openaire +2 more sources
Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates
2023ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that resulted in more than 6-million deaths worldwide. The virus encodes several non-structural proteins (Nsps) that contain elements capable of disrupting cellular processes.
Chanbora, Chea +4 more
openaire +2 more sources