Results 171 to 180 of about 5,596 (181)

MAC1 mediates LPS‐induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Glia, 2007
AbstractMicroglia‐derived superoxide is critical for the inflammation‐induced selective loss of dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly defined. Using neuron‐glia and microglia‐enriched cultures from mice deficient in the MAC1 receptor (MAC1−/−), we demonstrate that lipopolysaccharide (LPS ...
Belinda Wilson, Jau-Shyong Hong, Michelle L Block   +2 more
exaly   +3 more sources

Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor

Biochemical and Biophysical Research Communications, 2020
The underlying mechanism of viral infection as a risk factor for Parkinson's disease (PD), the second most common neurodegenerative disease, remains unclear.We used Mac-1-/- and gp91phox-/- transgene animal models to investigate the mechanisms by which poly I:C, a mimic of virus double-stranded RNA, induces PD neurodegeneration.Poly I:C was ...
Weixing Xu, Yinxi Wang, Huihui Quan, Dan Liu, Huifeng Zhang, Yuze Qi, Qingru Li, Jieying Liao, Hui-Ming Gao, Jing Huang, Hui Zhou   +10 more
openaire   +2 more sources

Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates

2023
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that resulted in more than 6-million deaths worldwide. The virus encodes several non-structural proteins (Nsps) that contain elements capable of disrupting cellular processes.
Chanbora, Chea, Duck-Yeon, Lee, Jiro, Kato, Hiroko, Ishiwata-Endo, Joel, Moss   +4 more
openaire   +2 more sources

High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021
Chandrabose Selvaraj, Dhurvas Chandrasekaran Dinesh, Umesh Panwar   +2 more
exaly  

The essential liaison of two copper proteins: the Cu-sensing transcription factor Mac1 and the Cu/Zn superoxide dismutase Sod1 in Saccharomyces cerevisiae

Current Genetics, 2022
Despina Alexandraki
exaly  

Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation

MSphere, 2019
Zhendong Cai, Ling Lu
exaly  

Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus

Fungal Genetics and Biology, 2017
Zhendong Cai, Nanbiao Long, Chuan-Chao Dai   +2 more
exaly  

Independent Metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae

Eukaryotic Cell, 2005
Amanda J Bird, Dennis R Winge
exaly  

Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model

International Journal of Cancer, 2004
Michael C Bibby, Mark Lucock, Anna Nicolaou   +2 more
exaly  

Faculty Opinions recommendation of Structures of the cuprous-thiolate clusters of the Mac1 and Ace1 transcriptional activators.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2002
openaire   +1 more source