Reviewer #1 (Public review): The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
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Copper Differentially Regulates the Activity and Degradation of Yeast Mac1 Transcription Factor [PDF]
Journal of Biological Chemistry, 1998 Copper is an essential metal ion that is toxic when accumulated to high intracellular concentrations. The yeast Mac1 protein is a copper-sensing transcription factor that is essential for both the activation and inactivation of genes required for high affinity copper ion transport.
Simon Labbe, Dennis J Thiele
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Identification of a copper-induced intramolecular interaction in the transcription factor Mac1 from Saccharomyces cerevisiae [PDF]
EMBO Journal, 1998 Mac1 mediates copper (Cu)-dependent expression of genes involved in high-affinity uptake of copper ions in Saccharomyces cerevisiae. Mac1 is a transcriptional activator in Cu-deficient cells, but is inhibited in Cu-replete cells. Mac1 resides within the nucleus in both Cu-deficient and Cu-loaded cells.
Laran T Jensen, Dennis R Winge
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Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]
SLAS Discovery, 2020 ABSTRACTSmall molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection. A high-throughput assay based on differential scanning fluorimetry (DSF) was
Nemanja Vuksanovic +2 more
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High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021 SARS-CoV-2 encodes the Mac1 domain within the large nonstructural protein 3 (Nsp3), which has an ADP-ribosylhydrolase activity conserved in other coronaviruses. The enzymatic activity of Mac1 makes it an essential virulence factor for the pathogenicity of coronavirus (CoV).
Chandrabose Selvaraj +2 more
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Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening [PDF]
Antiviral Research, 2022 ABSTRACTThe emergence of several zoonotic viruses in the last twenty years, especially the pandemic outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with pandemic potential. Developing a diverse drug portfolio will be critical for our ability to rapidly respond to novel coronaviruses (CoVs) and other viruses with ...
Yousef M O Alhammad +2 more
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Mac1+/Gr1+ cells contribute to transfusion-related acute lung injury
Transfusion and Apheresis Science, 2013Transfusion-related acute lung injury (TRALI) is a serious complication associated with blood transfusion and can cause transfusion associated fatalities. Both antibody dependent and non-dependent mechanisms are involved in TRALI, as proposed over the past years.
Xing-bin, Hu +4 more
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Mapping of the DNA Binding Domain of the Copper-responsive Transcription Factor Mac1 from Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 1998 Mac1 from Saccharomyces cerevisiae activates transcription of genes, including CTR1 in copper-deficient cells. N-terminal fusions of Mac1 with the herpes simplex VP16 activation domain were used to show that residues 1-159 in Mac1 constitute the minimal DNA binding domain.
Laran T Jensen +2 more
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Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates
2023ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that resulted in more than 6-million deaths worldwide. The virus encodes several non-structural proteins (Nsps) that contain elements capable of disrupting cellular processes.
Chanbora, Chea +4 more
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Structures of the Cuprous-Thiolate Clusters of the Mac1 and Ace1 Transcriptional Activators
Biochemistry, 2002X-ray absorption spectroscopy on the minimal copper-regulatory domains of the two copper-regulated transcription factors (Ace1 and Mac1) in Saccharomyces cerevisiae revealed the presence of a remarkably similar polycopper cluster in both proteins. The Cu-regulatory switch motif of Mac1 consisting of the C-terminal first Cys-rich motif, designated the ...
Brown, K. +5 more
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