Results 161 to 170 of about 5,596 (181)
Reviewer #2 (Public review): The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein encoded as a small domain at the N terminus of nonstructural protein 3.
Srivatsan Parthasarathy +2 more
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Mac1 Positive Cells Are Required for Enhancement of Splenocytes Proliferation Caused by Bisphenol A
Bioscience, Biotechnology and Biochemistry, 2004 We examined the effects of bisphenol A (BPA) on immune cells and it was shown that BPA upregulated the proliferation of murine splenocytes stimulated with Concanavalin A (ConA). The upregulating effects of BPA were removed with depleting Mac1+ cells from the splenocytes. This study provides evidence for the first time that Mac1+ cells were required for
Ono Hiroshi
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Identification of a copper-induced intramolecular interaction in the transcription factor Mac1 from Saccharomyces cerevisiae [PDF]
EMBO Journal, 1998 Mac1 mediates copper (Cu)-dependent expression of genes involved in high-affinity uptake of copper ions in Saccharomyces cerevisiae. Mac1 is a transcriptional activator in Cu-deficient cells, but is inhibited in Cu-replete cells. Mac1 resides within the nucleus in both Cu-deficient and Cu-loaded cells.
Laran T Jensen, Dennis R Winge
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Development (Cambridge), 2012 International audienceTo ensure fertility, complex somatic and germinal cell proliferation and differentiation programs must be executed in flowers.
Chung-Ju Rachel Wang +2 more
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Copper Differentially Regulates the Activity and Degradation of Yeast Mac1 Transcription Factor [PDF]
Journal of Biological Chemistry, 1998 Copper is an essential metal ion that is toxic when accumulated to high intracellular concentrations. The yeast Mac1 protein is a copper-sensing transcription factor that is essential for both the activation and inactivation of genes required for high affinity copper ion transport.
Zhiwu Zhu +2 more
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Mac1+/Gr1+ cells contribute to transfusion-related acute lung injury
Transfusion and Apheresis Science, 2013Transfusion-related acute lung injury (TRALI) is a serious complication associated with blood transfusion and can cause transfusion associated fatalities. Both antibody dependent and non-dependent mechanisms are involved in TRALI, as proposed over the past years.
Xing-bin, Hu +4 more
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Mapping of the DNA Binding Domain of the Copper-responsive Transcription Factor Mac1 from Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 1998 Mac1 from Saccharomyces cerevisiae activates transcription of genes, including CTR1 in copper-deficient cells. N-terminal fusions of Mac1 with the herpes simplex VP16 activation domain were used to show that residues 1-159 in Mac1 constitute the minimal DNA binding domain.
Laran T Jensen +2 more
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Current Genetics, 2019
While it is known that ScRad9 DNA damage checkpoint protein is recruited to damaged DNA by recognizing specific histone modifications, here we report a different way of Rad9 recruitment on chromatin under non DNA damaging conditions. We found Rad9 to bind directly with the copper-modulated transcriptional activator Mac1, suppressing both its DNA ...
Kalliopi Gkouskou +2 more
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While it is known that ScRad9 DNA damage checkpoint protein is recruited to damaged DNA by recognizing specific histone modifications, here we report a different way of Rad9 recruitment on chromatin under non DNA damaging conditions. We found Rad9 to bind directly with the copper-modulated transcriptional activator Mac1, suppressing both its DNA ...
Kalliopi Gkouskou +2 more
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Biochemical Journal, 2020
The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results of other groups first and explain the differences from our results.
Yong-Sung Park +3 more
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The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results of other groups first and explain the differences from our results.
Yong-Sung Park +3 more
openaire +2 more sources