Results 51 to 60 of about 156,214 (332)

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion [PDF]

, 2004
Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by global reduction in cerebral cortical volume. The microcephalic brain has a volume comparable to that of early hominids, raising the possibility that some MCPH genes may have ...
Abeysinghe, Aota, Benson, Bernardi, Bond, Bond, Chen, Chenn, Chuzhanova, Clark, Crandall, Dewyse, do Carmo Avides, Duret, Endo, Evans, Galtier, Gould, Hughes, Jurka, Kent, Kouprina, Kreitman, McCreary, McDonald, Mochida, Morgenstern, Noskov, Polushin, Rehen, Riparbelli, Ripoll, Roberts, Rudiger, Sharp, Sharp, Tobias, Wood, Yang, Yang, Zhang   +40 more
core   +3 more sources

Japanese macaque phonatory physiology

Journal of Experimental Biology, 2018
While the call repertoire and its communicative function is relatively well explored in Japanese macaques (Macaca fuscata), little empirical data is available on the physics and the physiology of this species' vocal production mechanism. Here, a 6 year old female Japanese macaque was trained to phonate under an operant conditioning paradigm.
Christian T. Herbst, Hiroki Koda, Takumi Kunieda, Juri Suzuki, Maxime Garcia, W. Tecumseh Fitch, Takeshi Nishimura   +6 more
openaire   +2 more sources

Macaque–human interactions and the societal perceptions of macaques in Singapore [PDF]

American Journal of Primatology, 2009
AbstractHumans and long‐tailed macaques (Macaca fascicularis) interface in several locations in Singapore. We investigated six of these interface zones to assess the level of conflict between the two species. We observed macaque‐to‐human interactions and distributed questionnaires to residents and visitors of nature reserves.
John Chih Mun, Sha, Michael D, Gumert, Benjamin P Y-H, Lee, Lisa, Jones-Engel, Sharon, Chan, Agustín, Fuentes   +5 more
openaire   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS

Pathogens, 2021
Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage.
Sonia Moretti, Sara Virtuoso, Leonardo Sernicola, Stefania Farcomeni, Maria Teresa Maggiorella, Alessandra Borsetti   +5 more
doaj   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Visual and eye movement functions of the posterior parietal cortex [PDF]

, 1989
Lesions of the posterior parietal area in humans produce interesting spatial-perceptual and spatial-behavioral deficits. Among the more important deficits observed are loss of spatial memories, problems representing spatial relations in models or ...
Andersen, Richard A.
core   +1 more source

Positional Inference in Rhesus Macaques

Animal Cognition, 2020
Understanding how organisms make transitive inferences is critical to understanding their general ability to learn serial relationships. In this context, transitive inference (TI) can be understood as a specific heuristic that applies broadly to many different serial learning tasks, which have been the focus of hundreds of studies involving dozens of ...
Greg Jensen, Vincent P. Ferrera, Herbert S. Terrace   +2 more
openaire   +3 more sources

Experimental Infection of Rhesus and Pig-Tailed Macaques with Macaque Rhadinoviruses [PDF]

Journal of Virology, 1999
ABSTRACT The recognition of naturally occurring rhadinoviruses in macaque monkeys has spurred interest in their use as models for human infection with Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). Rhesus macaques ( Macaca mulatta ) and pig-tailed macaques ( Macaca nemestrina
K G, Mansfield, S V, Westmoreland, C D, DeBakker, S, Czajak, A A, Lackner, R C, Desrosiers   +5 more
openaire   +2 more sources

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source