Results 81 to 90 of about 1,074,730 (288)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular BiomedicineIntegrating Artificial Intelligence (AI) across numerous disciplines has transformed the worldwide landscape of pandemic response. This review investigates the multidimensional role of AI in the pandemic, which arises as a global health crisis, and its ...
Mayur Suresh Gawande +5 more
doaj +1 more source
OrMAC: A Hybrid MAC Protocol Using Orthogonal Codes for Channel Access in M2M Networks
Sensors, 2017 This paper proposes a hybrid medium access protocol named orthogonal coded medium access control (OrMAC), which extends the principle of distributed queuing collision avoidance protocol (DQCA) of wireless local area network (WLAN) to delay-sensitive ...
Ethungshan Shitiri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2018 Random Access Channel (RACH) has been identified as one of the major bottlenecks for accommodating massive number of machine-to-machine (M2M) users in LTE networks, especially for the case of burst arrival of connection requests.
Al-Zubaidy, Hussein +4 more
core +1 more source
Toward a Secure Future: An Integrated Framework for PII Detection Using NLP and Visual Analysis
IEEE AccessSafeguarding Personally Identifiable Information (PII) is critical to prevent data breaches and identity theft in the era of digital services. This paper presents a hybrid PII detection and secure verification system that integrates rule-based regular ...
S. Sheela +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Grouping-Based Random Access Collision Control for Massive Machine-Type Communication
, 2017 Massive Machine-Type Communication (mMTC) is expected to be strongly supported by future 5G wireless networks. Its deployment, however, is seriously challenged by the high risk of random access (RA) collision. A popular concept is to reduce RA collisions
Han, Bin, Schotten, Hans D.
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source