Results 21 to 30 of about 1,789,694 (253)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Development of a Novel MultiBody Mechatronic Model for Five-Axis CNC Machine Tool [PDF]
, 2015 The paper presents the development of a mechatronic hybrid model for Geiss five-axis CNC machine tool using MultiBody-System (MBS) approach. The motion control systems comprising electrical and mechanical elements are analyzed and modeled.
Papananias, M. +2 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A particle swarm optimisation-based Grey prediction model for thermal error compensation on CNC machine tools [PDF]
, 2015 Thermal errors can have a significant effect on CNC machine tool accuracy. The thermal error compensation system has become a cost-effective method of improving machine tool accuracy in recent years.
Abdulshahed, Ali +2 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Part Form Errors Predicted from Machine Tool Performance Measurements [PDF]
, 1997 Machine tool performance testing, as defined by IS0 230 and ANSI B5.54 has been successfully used to maintain and improve the accuracy and repeatability of production-level machine tools.
Farabaugh, F. +3 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Effect of Hydrostatic Guideway on Reduction of Machine Tool Ram Vibration [PDF]
, 2018 The guideways provide translational movement of machine parts and have a major impact on the resulting utility properties of the ma-chine tools, such as machining accuracy, surface quality and productivity.
Lazák T., Stach E., Sulitka M.
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source