Results 41 to 50 of about 5,306,001 (276)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scientific ReportsGear skiving is an efficient and precise method for gear manufacturing. Traditional conical skiving tools feature a structural relief angle on the flank and a plane rake face, which often leads to inconsistent accuracy after regrinding and an ...
Jiaxue Ji +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Sidney Machine Tool Company lathe photograph
This photograph shows a lathe at the Sidney Machine Tool Company. Sidney Tool Company was founded in 1905 by Alfred C. Getz in Sidney, Ohio. Getz was also acting plant manager for Monarch Machine Tool, also in Sidney, during the same time.
Sidney Machine Tool Company
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Research on cutting mechanism and process optimization method of gear skiving
Scientific ReportsThe cutting force and cutting temperature have a significant impact on the service life and durability of gear skiving cutters. Due to unreasonable design, the existing process parameters lead to dramatically nonuniform cutting force and cutting ...
Peng Wang +5 more
doaj +1 more source
Effects of Cooling Systems on the Thermal Behaviour of Machine Tools and Thermal Error Models
Journal of Machine Engineering, 2020 Today, cooling systems are increasingly applied to the structure of machine tools (MT). Unfortunately, to date there have been few efforts to precisely control these cooling systems, which inhibits the full utilisation of their potential to improve MT ...
Martin Mareš +4 more
doaj +1 more source