Results 41 to 50 of about 377,457 (261)
Advances in Mechanical Engineering, 2022 There is inevitably an angular offset during contact of mechanical structures such as roller bearings or gears. Most of the previous contact models involve the contact between two parallel cylinders.
Tieneng Guo, Ruguo Ji, Yunfei Ma
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Research on cutting mechanism and process optimization method of gear skiving
Scientific ReportsThe cutting force and cutting temperature have a significant impact on the service life and durability of gear skiving cutters. Due to unreasonable design, the existing process parameters lead to dramatically nonuniform cutting force and cutting ...
Peng Wang +5 more
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Research on the dynamic identification method of weak parts in cantilever structures
Science Progress, 2021 Determining the weak parts of a structure is one of the key issues in the field of machine tool stiffness improvement. However, studies show that overcoming the static deformation with acquisition difficulty is a complex problem in practical structures ...
Tieneng Guo +4 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Modeling and Error Compensation for Concentric Grinding of Spherical Surfaces
MicromachinesTo improve the form accuracy of spherical surfaces generated by cup-wheel grinding, this paper presents a geometric modeling and error compensation method for concentric grinding of spherical surfaces.
Baozhen Li +4 more
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