Results 51 to 60 of about 471,211 (302)
Research on cutting mechanism and process optimization method of gear skiving
Scientific ReportsThe cutting force and cutting temperature have a significant impact on the service life and durability of gear skiving cutters. Due to unreasonable design, the existing process parameters lead to dramatically nonuniform cutting force and cutting ...
Peng Wang +5 more
doaj +1 more source
Thermal Analysis for Condition Monitoring of Machine Tool Spindles
, 2012 Decreasing tolerances on parts manufactured, or inspected, on machine tools increases the requirement to have a greater understanding of machine tool capabilities, error sources and factors affecting asset availability. Continuous usage of a machine tool
Willoughby, P. +7 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Sidney Machine Tool Company lathe photograph
This photograph shows a lathe at the Sidney Machine Tool Company. Sidney Tool Company was founded in 1905 by Alfred C. Getz in Sidney, Ohio. Getz was also acting plant manager for Monarch Machine Tool, also in Sidney, during the same time.
Sidney Machine Tool Company
core +2 more sources
Research on the dynamic hammering method for identifying weak parts in cantilever structures
Science Progress, 2021 Identification of the vulnerabilities in the structural stiffness is one of the most crucial issues in improving this property of machine tools. In this paper, the Flexibility Matrix Diagonal element method, based on hammer testing, is proposed as an ...
Tieneng Guo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 In recent years, needs for micro drilling are increasing, accompanying the development of higher wiring density of printed circuit board (PCB). When drilling PCB for the purpose of making the electric through holes, it has been said that the drill ...
Hiromi YOSHIMURA +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Advances in Mechanical Engineering, 2019 Analyzing of nonlinear carrying performance of hydrostatic ram is among key research questions to improve heavy machine tools because the machining precision will be directly influenced by it.
Yumo Wang +5 more
doaj +1 more source